Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 7/20 | 0.46 |
| ▸ | ROCK1 | Q13464 | 7/20 | 0.46 |
| ▸ | CDC42BPB | Q9Y5S2 | 6/20 | 0.46 |
| ▸ | CDC42BPA | Q5VT25 | 2/20 | 0.43 |
| ▸ | KCNMA1 | Q12791 | 2/20 | 0.39 |
| ▸ | STK4 | Q13043 | 1/20 | 0.39 |
| ▸ | STK3 | Q13188 | 1/20 | 0.39 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 2/20 | 0.37 |
| ▸ | CDK7 | P50613 | 1/20 | 0.37 |
| ▸ | CDK9 | P50750 | 1/20 | 0.37 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.37 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.36 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.36 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.36 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.36 |
| ▸ | CTSB | P07858 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3222860 | 0.83 | KCNMA1 (0.41) | KCNMA1 | |
| SCHEMBL3229389 | 0.82 | AKT2 (0.47) | ROCK2ROCK1CDC42BPBKCNMA1HTR1A | |
| SCHEMBL20689362 | 0.80 | KCNMA1 (0.48) | ROCK2ROCK1CDC42BPBCDC42BPAKCNMA1 | |
| SCHEMBL3225528 | 0.80 | CKS1B (0.50) | — | |
| SCHEMBL3628431 | 0.79 | FLT3 (0.47) | ROCK2ROCK1CDC42BPBCDK9HRH4 | |
| SCHEMBL3616034 | 0.77 | HTR2A (0.59) | HTR1AHTR2AHTR2CSLC6A4 | |
| SCHEMBL3214631 | 0.77 | ROCK2 (0.45) | ROCK2ROCK1CDC42BPBCDC42BPAKCNMA1 | |
| SCHEMBL3220338 | 0.77 | PIM1 (0.50) | — | |
| SCHEMBL3267839 | 0.77 | CKS1B (0.47) | — | |
| SCHEMBL20689453 | 0.76 | KCNMA1 (0.52) | ROCK2ROCK1CDC42BPBKCNMA1CDK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010024980-A1 | 4'-AMINO CYCLIC COMPOUNDS HAVING 5-HT6 RECEPTOR AFFINITY | MEMORY PHARMACEUTICALS CORPORATION (US) | 2010-03-04 | — | — | WO | disclosed |
| US-20100056491-A1 | 4'-AMINO CYCLIC COMPOUNDS HAVING 5-HT6 RECEPTOR AFFINITY | MEMORY PHARMACEUTICALS CORPORATION (US) | 2010-03-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100056491-A1 | 4'-AMINO CYCLIC COMPOUNDS HAVING 5-HT6 RECEPTOR AFFINITY | HTR6, HTR4, HTR3B | ROCK2 2180/4885ROCK1 2069/4885CDC42BPB 1903/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.