Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 3/20 | 0.49 |
| ▸ | HTR2A | P28223 | 3/20 | 0.49 |
| ▸ | HTR2C | P28335 | 2/20 | 0.49 |
| ▸ | DRD2 | P14416 | 1/20 | 0.49 |
| ▸ | HSD11B1 | P28845 | 6/20 | 0.48 |
| ▸ | CHI3L1 | P36222 | 1/20 | 0.47 |
| ▸ | CHIT1 | Q13231 | 1/20 | 0.47 |
| ▸ | CHI3L2 | Q15782 | 1/20 | 0.47 |
| ▸ | CHIA | Q9BZP6 | 1/20 | 0.47 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.43 |
| ▸ | MALT1 | Q9UDY8 | 2/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | KIF18A | Q8NI77 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3209933 | 0.88 | HSD11B1 (0.54) | HSD11B1NFE2L2MALT1 | |
| SCHEMBL3219593 | 0.87 | HSD11B1 (0.51) | KCNH2DRD2HSD11B1CHI3L1CHIT1 | |
| SCHEMBL3214405 | 0.85 | HSD11B1 (0.52) | HSD11B1HRH3MEN1KMT2ATDP1 | |
| SCHEMBL3220012 | 0.85 | HSD11B1 (0.69) | HSD11B1 | |
| SCHEMBL3218488 | 0.79 | HRH4 (0.49) | HTR2AHTR2CMALT1 | |
| SCHEMBL3219142 | 0.76 | HSD11B1 (0.58) | HSD11B1MALT1KIF18A | |
| SCHEMBL3216598 | 0.75 | TRPV1 (0.61) | KCNH2HSD11B1MALT1MEN1KMT2A | |
| SCHEMBL3214389 | 0.75 | MALT1 (0.56) | HSD11B1NFE2L2MALT1KIF18A | |
| SCHEMBL3212450 | 0.73 | HSD11B1 (0.67) | HSD11B1 | |
| SCHEMBL3209868 | 0.73 | HSD11B1 (0.53) | HSD11B1MALT1KIF18A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100029648-A1 | 11-Beta HSD1 Inhibitors | XIANG JASON SHAOYUN | 2010-02-04 | — | — | US | disclosed |
| US-7632838-B2 | 11-beta HSD1 inhibitors | WYETH (US) | 2009-12-15 | — | — | US | disclosed |
| US-20070219198-A1 | 11-Beta HSD 1 inhibitors | WYETH (US) | 2007-09-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100029648-A1 | 11-Beta HSD1 Inhibitors | HSD11B1, HSD3B1, HSD11B2 | KCNH2 4537/4885HTR2A 2280/4885HTR2C 1366/4885 |
| US-20070219198-A1 | 11-Beta HSD 1 inhibitors | HSD11B1, HSD11B2, HSD3B1 | KCNH2 4375/4885HTR2A 1356/4885HTR2C 806/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.