Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
| ▸ | RECQL | P46063 | 1/20 | 0.51 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.45 |
| ▸ | DRD4 | P21917 | 2/20 | 0.45 |
| ▸ | PDE10A | Q9Y233 | 4/20 | 0.43 |
| ▸ | DRD2 | P14416 | 2/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.40 |
| ▸ | GRM5 | P41594 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3222995 | 0.82 | KDM4E (0.52) | KDM4ERECQLHSD11B1DRD4PDE10A | |
| SCHEMBL3221653 | 0.81 | HSD11B1 (0.53) | HSD11B1PDE10A | |
| Quinoline SCHEMBL28264935 | 0.77 | ALDH1A1 (0.50) | KDM4EPDE10AALDH1A1GRM5 | |
| SCHEMBL5468251 | 0.74 | HSD11B1 (0.52) | KDM4ERECQLHSD11B1DRD4DRD2 | |
| SCHEMBL3202120 | 0.74 | KDM4E (0.52) | KDM4ERECQLHSD11B1DRD2HTR2A | |
| SCHEMBL3210155 | 0.74 | HSD11B1 (0.53) | KDM4ERECQLHSD11B1DRD2HTR2A | |
| SCHEMBL28265035 | 0.74 | NPC1 (0.39) | KDM4EPDE10AHDAC2ALDH1A1MAPT | |
| SCHEMBL5471257 | 0.73 | HSD11B1 (0.48) | KDM4ERECQLHSD11B1DRD4DRD2 | |
| SCHEMBL3291180 | 0.71 | KDM4E (0.67) | KDM4ERECQLHSD11B1DRD4DRD2 | |
| SCHEMBL3287137 | 0.71 | KDM4E (0.61) | KDM4ERECQLHSD11B1DRD4DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100029648-A1 | 11-Beta HSD1 Inhibitors | XIANG JASON SHAOYUN | 2010-02-04 | — | — | US | disclosed |
| US-7632838-B2 | 11-beta HSD1 inhibitors | WYETH (US) | 2009-12-15 | — | — | US | disclosed |
| US-20070219198-A1 | 11-Beta HSD 1 inhibitors | WYETH (US) | 2007-09-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100029648-A1 | 11-Beta HSD1 Inhibitors | HSD11B1, HSD3B1, HSD11B2 | KDM4E 1296/4885RECQL 3597/4885HSD11B1 1/4885 |
| US-20070219198-A1 | 11-Beta HSD 1 inhibitors | HSD11B1, HSD11B2, HSD3B1 | KDM4E 1360/4885RECQL 3750/4885HSD11B1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.