Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | CCR1 | P32246 | 1/20 | 0.48 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.48 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.48 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.48 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.48 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.48 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | AKR1C3 | P42330 | 7/20 | 0.45 |
| ▸ | ACHE | P22303 | 1/20 | 0.45 |
| ▸ | HTR6 | P50406 | 1/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3216585 | 1.00 | ALOX15 (0.52) | ALOX15KMT2ACCR1PSEN1PSEN2 | |
| SCHEMBL6186634 | 0.83 | ALOX15 (0.53) | ALOX15KMT2APSEN1PSEN2APH1B | |
| SCHEMBL15924853 | 0.83 | MAPT (0.45) | KMT2ACCR1ALDH1A1HTR6EPHX2 | |
| SCHEMBL10067926 | 0.82 | CHRM4 (0.56) | ALOX15KMT2ACCR1PSEN1PSEN2 | |
| SCHEMBL31717377 | 0.79 | HTT (0.53) | ALDH1A1HTTEPHX2 | |
| SCHEMBL15917032 | 0.78 | PRKACA (0.57) | ALOX15KMT2ACCR1ALDH1A1HTT | |
| SCHEMBL15917140 | 0.78 | PRKACA (0.57) | ALOX15KMT2ACCR1ALDH1A1HTT | |
| SCHEMBL3221082 | 0.78 | OPRK1 (0.54) | CCR1HTR6EPHX2 | |
| SCHEMBL15917030 | 0.78 | PRKACA (0.57) | ALOX15KMT2ACCR1ALDH1A1HTT | |
| SCHEMBL3221077 | 0.78 | OPRK1 (0.54) | CCR1HTR6EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100035873-A1 | Diaryl Compounds and Uses Thereof | PFIZER INC | 2010-02-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100035873-A1 | Diaryl Compounds and Uses Thereof | OPRK1, OPRD1, OPRL1 | ALOX15 2226/4885KMT2A 1382/4885CCR1 340/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.