Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K11 | Q16584 | 2/20 | 0.56 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.56 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.56 |
| ▸ | SGK1 | O00141 | 1/20 | 0.56 |
| ▸ | IKBKB | O14920 | 1/20 | 0.56 |
| ▸ | AURKA | O14965 | 1/20 | 0.56 |
| ▸ | CHUK | O15111 | 1/20 | 0.56 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.56 |
| ▸ | ABL1 | P00519 | 1/20 | 0.56 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.56 |
| ▸ | INSR | P06213 | 1/20 | 0.56 |
| ▸ | LCK | P06239 | 1/20 | 0.56 |
| ▸ | CDK1 | P06493 | 1/20 | 0.56 |
| ▸ | IGF1R | P08069 | 1/20 | 0.56 |
| ▸ | MET | P08581 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | SRC | P12931 | 1/20 | 0.56 |
| ▸ | FLT1 | P17948 | 1/20 | 0.56 |
| ▸ | CDK2 | P24941 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ammonia Solution, Strong SCHEMBL27758936 | 0.98 | MAP3K11 (0.55) | MAP3K11MAPK14ROCK2SGK1IKBKB | |
| SCHEMBL3047278 | 0.85 | PKM (0.61) | MAP3K11MAPK14ROCK2SGK1IKBKB | |
| SCHEMBL3697284 | 0.85 | MAPK14 (0.55) | MAP3K11MAPK14ROCK2SGK1IKBKB | |
| SCHEMBL13293706 | 0.84 | FAAH (0.55) | MAPK14ROCK2FAAHHTR1AHTR1D | |
| SCHEMBL20752055 | 0.83 | MAP3K11 (0.56) | MAP3K11MAPK14FAAHHTR1AHTR1D | |
| SCHEMBL5751064 | 0.82 | FAAH (0.54) | MAP3K11MAPK14ROCK2SGK1IKBKB | |
| SCHEMBL18941210 | 0.82 | FAAH (0.63) | MAPK14FAAHHTR1AHTR1DHTR1B | |
| SCHEMBL3695011 | 0.81 | CHKA (0.53) | MAP3K11MAPK14ROCK2SGK1IKBKB | |
| SCHEMBL5751758 | 0.81 | DRD4 (0.56) | MAP3K11MAPK14KCNH2FAAHHTR1A | |
| SCHEMBL26134148 | 0.81 | FAAH (0.55) | MAPK14ROCK2KCNH2FAAHDRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101544592-B | Process for preparation of N-arylsulfonyl-3-substituted indoles | SUVEN LIFE SCIENCES LTD | 2013-08-21 | — | — | CN | disclosed |
| US-8470830-B2 | 5-(heterocyclyl)alkyl-N-(arylsulfonyl)indole compounds and their use as 5-HT6 ligands | SUVEN LIFE SCIENCES LIMITED (IN) | 2013-06-25 | — | — | US | disclosed |
| CN-101553467-B | 5-(heterocyclyl)alkyl-N-(arylsulfonyl)indole compounds and their use as 5-HT6 ligands | SUVEN LIFE SCIENCES LTD. (IN) | 2011-12-07 | — | — | CN | disclosed |
| EP-2114878-B1 | 5-(HETEROCYCLYL)ALKYL-N-(ARYLSULFONYL)INDOLE COMPOUNDS AND THEIR USE AS 5-HT6 LIGANDS | SUVEN LIFE SCIENCES LTD (IN) | 2010-12-15 | — | — | EP | disclosed |
| US-20100041673-A1 | 5-(HETEROCYCLYL)ALKYL-N-(ARYLSULFONYL)INDOLE COMPOUNDS AND THEIR USE AS 5-HT6 LIGANDS | SUVEN LIFE SCIENCES LIMITED (IN) | 2010-02-18 | — | — | US | disclosed |
| EP-2114878-A1 | 5-(HETEROCYCLYL)ALKYL-N-(ARYLSULFONYL)INDOLE COMPOUNDS AND THEIR USE AS 5-HT6 LIGANDS | Suven Life Sciences Limited (IN) | 2009-11-11 | — | — | EP | disclosed |
| CN-101553467-A | 5-(heterocyclyl)alkyl-N-(arylsulfonyl)indole compounds and their use as 5-HT6 ligands | SUVEN LIFE SCIENCES LTD (IN) | 2009-10-07 | — | — | CN | disclosed |
| WO-2008084492-A1 | 5-(HETEROCYCLYL)ALKYL-N-(ARYLSULFONYL)INDOLE COMPOUNDS AND THEIR USE AS 5-HT6 LIGANDS | SUVEN LIFE SCIENCES LIMITED (IN) | 2008-07-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100041673-A1 | 5-(HETEROCYCLYL)ALKYL-N-(ARYLSULFONYL)INDOLE COMPOUNDS AND THEIR USE AS 5-HT6 LIGANDS | HTR6, HTR5A, HTR2C | MAP3K11 2721/4885MAPK14 2038/4885ROCK2 3592/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.