Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Nitric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.47 |
| ▸ | GLA | P06280 | 5/20 | 0.47 |
| ▸ | MEN1 | O00255 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | HTT | P42858 | 4/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | MAOA | P21397 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | CASP1 | P29466 | 2/20 | 0.45 |
| ▸ | CASP7 | P55210 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.45 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.45 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Toluic Acid SCHEMBL8112942 | 0.83 | KDM4E (0.44) | KDM4EKMT2ASMN1; SMN2MEN1MAPT | |
| 4-Methylbenzoic Acid SCHEMBL8112941 | 0.83 | MAPT (0.50) | KDM4EKMT2ASMN1; SMN2GLAMEN1 | |
| Nitric Acid SCHEMBL16898979 | 0.82 | KDM4E (0.46) | KDM4EKMT2ASMN1; SMN2GLAMEN1 | |
| Nitric Acid SCHEMBL16898980 | 0.82 | KDM4E (0.43) | KDM4EKMT2ASMN1; SMN2GLAMEN1 | |
| SCHEMBL1502392 | 0.82 | ALDH1A1 (0.62) | KDM4EKMT2ASMN1; SMN2GLAMAPT | |
| SCHEMBL13400206 | 0.79 | ALDH1A1 (0.59) | KDM4EKMT2ASMN1; SMN2GLAMAPT | |
| SCHEMBL20291524 | 0.77 | CYP3A4 (0.61) | KDM4EKMT2ASMN1; SMN2GLAMEN1 | |
| Acridine SCHEMBL31425247 | 0.77 | ALDH1A1 (0.65) | KDM4EKMT2AGLAMEN1MAPT | |
| Acridine SCHEMBL2772852 | 0.77 | ALDH1A1 (0.65) | KDM4EKMT2AGLAMEN1MAPT | |
| Acridine SCHEMBL27479825 | 0.77 | ALDH1A1 (0.65) | KDM4EKMT2AGLAMEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1594855-B1 | SIGNALLING COMPOUNDS FOR USE IN METHODS OF DETECTING HYDROGEN PEROXIDE | LUMIGEN INC (US) | 2014-01-22 | — | — | EP | disclosed |
| EP-2305690-B1 | Signalling compounds for use in methods of detecting hydrogen peroxide | LUMIGEN INC (US) | 2012-08-29 | — | — | EP | disclosed |
| US-7704752-B2 | Signalling compounds for use in methods of detecting hydrogen peroxide | LUMIGEN, INC. (US) | 2010-04-27 | — | — | US | disclosed |
| US-20100055800-A1 | Compositions for Chemiluminescent Detection of Hydrogen Peroxide | LUMIGEN, INC. (US) | 2010-03-04 | — | — | US | disclosed |
| US-20080261318-A1 | Signalling Compounds For Use In Methods Of Detecting Hydrogen Peroxide | LUMIGEN, INC. (US) | 2008-10-23 | — | — | US | disclosed |
| US-7390670-B2 | Signalling compounds and methods for detecting hydrogen peroxide | LUMIGEN, INC. (US) | 2008-06-24 | — | — | US | disclosed |
| US-6919463-B2 | Signalling compounds for use in methods of detecting hydrogen peroxide | LUMIGEN, INC. (US) | 2005-07-19 | — | — | US | disclosed |
| US-20040171098-A1 | Signalling compounds for use in methods of detecting hydrogen peroxide | LUMIGEN INC. | 2004-09-02 | — | — | US | disclosed |
| US-20040166539-A1 | Signalling compounds and methods for detecting hydrogen peroxide | LUMIGEN, INC. | 2004-08-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040171098-A1 | Signalling compounds for use in methods of detecting hydrogen peroxide | LPO, HAO2, HAO1 | KDM4E 4844/4885KMT2A 4848/4885SMN1; SMN2 4196/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.