Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 7/20 | 0.66 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.58 |
| ▸ | GBA1 | P04062 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3224518 | 0.89 | HSD11B1 (0.65) | HSD11B1CHRM4GBA1ALDH1A1GAA | |
| SCHEMBL3210396 | 0.87 | HSD11B1 (0.72) | HSD11B1GBA1ALDH1A1GAA | |
| SCHEMBL3213850 | 0.86 | HSD11B1 (0.78) | HSD11B1 | |
| SCHEMBL2961253 | 0.85 | SMN1; SMN2 (0.66) | CHRM4GBA1ALDH1A1GAA | |
| SCHEMBL2963390 | 0.85 | HSD11B1 (0.67) | HSD11B1CHRM4GBA1ALDH1A1 | |
| SCHEMBL2963306 | 0.83 | ALDH1A1 (0.68) | CHRM4ALDH1A1 | |
| SCHEMBL5439348 | 0.82 | HSD11B1 (0.72) | HSD11B1 | |
| SCHEMBL3198863 | 0.82 | HSD11B1 (0.81) | HSD11B1GBA1 | |
| SCHEMBL3210151 | 0.81 | HSD11B1 (0.75) | HSD11B1GBA1ALDH1A1GAA | |
| SCHEMBL2953059 | 0.81 | CHRM4 (0.53) | HSD11B1CHRM4GBA1ALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100029648-A1 | 11-Beta HSD1 Inhibitors | XIANG JASON SHAOYUN | 2010-02-04 | — | — | US | disclosed |
| US-7632838-B2 | 11-beta HSD1 inhibitors | WYETH (US) | 2009-12-15 | — | — | US | disclosed |
| EP-1981848-A2 | 11-BETA HSD1 INHIBITORS | Wyeth (US) | 2008-10-22 | — | — | EP | disclosed |
| US-20070219198-A1 | 11-Beta HSD 1 inhibitors | WYETH (US) | 2007-09-20 | — | — | US | disclosed |
| WO-2007092435-A2 | 11-BETA HSD1 INHIBITORS | WYETH (US) | 2007-08-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100029648-A1 | 11-Beta HSD1 Inhibitors | HSD11B1, HSD3B1, HSD11B2 | HSD11B1 1/4885CHRM4 4870/4885GBA1 3525/4885 |
| US-20070219198-A1 | 11-Beta HSD 1 inhibitors | HSD11B1, HSD11B2, HSD3B1 | HSD11B1 1/4885CHRM4 4818/4885GBA1 4014/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.