Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.67 |
| ▸ | HPGD | P15428 | 1/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | USP5 | P45974 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.49 |
| ▸ | MBTD1 | Q05BQ5 | 1/20 | 0.49 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | CASP3 | P42574 | 1/20 | 0.48 |
| ▸ | CASP7 | P55210 | 1/20 | 0.48 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3218831 | 0.89 | ALDH1A1 (0.56) | ALDH1A1KDM4ESMN1; SMN2HPGDKMT2A | |
| SCHEMBL17007430 | 0.84 | DHCR7 (0.64) | ALDH1A1KDM4EKMT2AMEN1LMNA | |
| SCHEMBL165947 | 0.81 | ALDH1A1 (0.67) | ALDH1A1KDM4ESMN1; SMN2HPGDKMT2A | |
| SCHEMBL164996 | 0.77 | ALDH1A1 (0.62) | ALDH1A1KDM4ESMN1; SMN2HPGDKMT2A | |
| SCHEMBL22233113 | 0.77 | ALDH1A1 (0.57) | ALDH1A1KDM4ESMN1; SMN2HPGDKMT2A | |
| SCHEMBL14847757 | 0.77 | RAB9A (0.55) | KDM4ETSHRLMNAMAPK1HSD11B1 | |
| SCHEMBL2962711 | 0.77 | CCR1 (0.60) | ALDH1A1KDM4ESMN1; SMN2HPGDKMT2A | |
| SCHEMBL21958453 | 0.75 | ALDH1A1 (0.55) | ALDH1A1KDM4ESMN1; SMN2HPGDKMT2A | |
| SCHEMBL17014228 | 0.74 | SMN1; SMN2 (0.59) | ALDH1A1KDM4ESMN1; SMN2HPGDKMT2A | |
| SCHEMBL14829559 | 0.74 | RAB9A (0.52) | KDM4EKMT2AMEN1TSHRLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100029648-A1 | 11-Beta HSD1 Inhibitors | XIANG JASON SHAOYUN | 2010-02-04 | — | — | US | disclosed |
| US-7632838-B2 | 11-beta HSD1 inhibitors | WYETH (US) | 2009-12-15 | — | — | US | disclosed |
| US-20070219198-A1 | 11-Beta HSD 1 inhibitors | WYETH (US) | 2007-09-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100029648-A1 | 11-Beta HSD1 Inhibitors | HSD11B1, HSD3B1, HSD11B2 | ALDH1A1 116/4885KDM4E 1296/4885SMN1; SMN2 3575/4885 |
| US-20070219198-A1 | 11-Beta HSD 1 inhibitors | HSD11B1, HSD11B2, HSD3B1 | ALDH1A1 123/4885KDM4E 1360/4885SMN1; SMN2 3686/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.