Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EYA3 | Q99504 | 7/20 | 1.00 |
| ▸ | CYP2C19 | P33261 | 6/20 | 1.00 |
| ▸ | CYP2C9 | P11712 | 5/20 | 0.82 |
| ▸ | TTR | P02766 | 4/20 | 0.69 |
| ▸ | MEN1 | O00255 | 1/20 | 0.69 |
| ▸ | BIRC5 | O15392 | 1/20 | 0.69 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.69 |
| ▸ | LMNA | P02545 | 1/20 | 0.69 |
| ▸ | PGR | P06401 | 1/20 | 0.69 |
| ▸ | HTR1A | P08908 | 1/20 | 0.69 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.69 |
| ▸ | DRD1 | P21728 | 1/20 | 0.69 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.69 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.69 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.69 |
| ▸ | PDE4A | P27815 | 1/20 | 0.69 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.69 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.69 |
| ▸ | DRD3 | P35462 | 1/20 | 0.69 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15698044 | 0.87 | EYA3 (1.00) | EYA3CYP2C19CYP2C9TTRMEN1 | |
| Benziodarone SCHEMBL31326233 | 0.82 | EYA3 (1.00) | EYA3CYP2C19CYP2C9TTRMEN1 | |
| Benziodarone SCHEMBL308541 | 0.82 | EYA3 (1.00) | EYA3CYP2C19CYP2C9TTRMEN1 | |
| SCHEMBL6490125 | 0.82 | EYA3 (0.69) | EYA3CYP2C19CYP2C9TTRMEN1 | |
| SCHEMBL30258441 | 0.82 | EYA3 (0.69) | EYA3CYP2C19CYP2C9TTRMEN1 | |
| SCHEMBL28245008 | 0.81 | CYP2C19 (0.79) | EYA3CYP2C19CYP2C9MEN1LMNA | |
| SCHEMBL8994710 | 0.80 | CYP2C19 (1.00) | EYA3CYP2C19CYP2C9LMNATHRA | |
| SCHEMBL3119701 | 0.80 | EYA3 (0.77) | EYA3CYP2C19CYP2C9TTRMEN1 | |
| SCHEMBL6336681 | 0.79 | EYA3 (0.75) | EYA3CYP2C19CYP2C9TTRMEN1 | |
| SCHEMBL15698032 | 0.79 | EYA3 (0.84) | EYA3CYP2C19CYP2C9TTRMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 64 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023058975-A1 | PHARMACEUTICAL COMPOSITION FOR INHIBITING HSP47 INCLUDING BENZOFURANYL HYDROXYPHENYL METHANONE DERIVATIVE | (주)이노보테라퓨틱스 | 2023-04-13 | — | — | WO | claimed |
| US-20050065208-A1 | Benzofuranes and their use in the treatment of atrial fibrillation | KARO BIO AB (SE) | 2005-03-24 | — | — | US | claimed |
| US-20040234592-A1 | Mixture containing thyroid hormone , ethanolamine and emulsifier | KARO BIO AB (SE) | 2004-11-25 | — | — | US | claimed |
| EP-1408958-A1 | BENZOFURANES AND THEIR USE IN THE TREATMENT OF ATRIAL FIBRILLATION | KARO BIO AB (SE) | 2004-04-21 | — | — | EP | claimed |
| EP-1404413-A2 | DERMATOLOGICAL FORMULATIONS | KARO BIO AB (SE) | 2004-04-07 | — | — | EP | claimed |
| EP-1398024-A2 | Uses for thyroid hormone compounds | KARO BIO AB (SE) | 2004-03-17 | — | — | EP | claimed |
| EP-0831769-B1 | NOVEL USES FOR THYROID HORMONES OR THYROID HORMONE-LIKE COMPOUNDS | KAROBIO AB (SE) | 2003-10-15 | — | — | EP | claimed |
| EP-1328265-A2 | NOVEL USES FOR THYROID HORMONES OR THYROID HORMONE-LIKE AGONIST COMPOUNDS FOR TREATING DERMIS CONDITIONS | KARO BIO AB (SE) | 2003-07-23 | — | — | EP | claimed |
| WO-2003009839-A1 | BENZOFURANES AND THEIR USE IN THE TREATMENT OF ATRIAL FIBRILLATION | KARO BIO AB (SE) | 2003-02-06 | — | — | WO | claimed |
| WO-2002089917-A2 | DERMATOLOGICAL FORMULATIONS | KARO BIO AB (SE) | 2002-11-14 | — | — | WO | claimed |
| US-20020123521-A1 | Treatment for dermal skin atrophy using thyroid hormone compounds or thyroid hormone-like compounds | KOO, CATHERINE, DR | 2002-09-05 | — | — | US | claimed |
| US-6380255-B1 | TOPICALLY APPLYING TO SKIN THYROID HORMONE COMPOUND TOGETHER WITH A BASE FOR THERAPY OF SKIN ATROPHY | KARO BIO AB (SE) | 2002-04-30 | — | — | US | claimed |
| WO-2002005834-A2 | NOVEL USES FOR THYROID HORMONES OR THYROID HORMONE-LIKE AGONIST COMPOUNDS FOR TREATING DERMIS CONDITIONS | KARO BIO AB (SE) | 2002-01-24 | — | — | WO | claimed |
| US-6221911-B1 | REDUCING SUBCUTANEOUS FAT DEPOSITS IN A SUBJECT; IMPROVING THE SKIN CONDITION OF A SUBJECT | KARO BIO AB (SE) | 2001-04-24 | — | — | US | claimed |
| EP-0831769-A2 | NOVEL USES FOR THYROID HORMONES OR THYROID HORMONE-LIKE COMPOUNDS | KARO BIO AB (SE) | 1998-04-01 | — | — | EP | claimed |
| WO-1996040048-A9 | NOVEL USES FOR THYROID HORMONES OR THYROID HORMONE-LIKE COMPOUNDS | — | 1997-03-27 | — | — | WO | claimed |
| WO-1996040048-A2 | NOVEL USES FOR THYROID HORMONES OR THYROID HORMONE-LIKE COMPOUNDS | KARO BIO AB (SE) | 1996-12-19 | — | — | WO | claimed |
| EP-0584186-B1 | RECEPTOR LIGANDS | KAROBIO AB (SE) | 1996-08-21 | — | — | EP | claimed |
| EP-0584186-A1 | RECEPTOR LIGANDS. | KAROBIO AB (SE) | 1994-03-02 | — | — | EP | claimed |
| WO-1992020331-A1 | RECEPTOR LIGANDS | KAROBIO AKTIEBOLAG (SE) | 1992-11-26 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050065208-A1 | Benzofuranes and their use in the treatment of atrial fibrillation | KCNH1, KCNJ2, KCNQ2 | EYA3 3572/4885CYP2C19 240/4885CYP2C9 246/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.