Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | HTR6 | P50406 | 2/20 | 0.51 |
| ▸ | AKR1C3 | P42330 | 9/20 | 0.47 |
| ▸ | AKR1C2 | P52895 | 5/20 | 0.45 |
| ▸ | ICMT | O60725 | 3/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HK1 | P19367 | 1/20 | 0.38 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.38 |
| ▸ | AR | P10275 | 1/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5794780 | 0.87 | HTR6 (0.53) | L3MBTL1HTR6AKR1C3AKR1C2ICMT | |
| SCHEMBL29444455 | 0.86 | L3MBTL1 (0.56) | L3MBTL1HTR6AKR1C3AKR1C2ICMT | |
| SCHEMBL17872017 | 0.86 | L3MBTL1 (0.56) | L3MBTL1HTR6AKR1C3AKR1C2ICMT | |
| SCHEMBL29228913 | 0.85 | HTR6 (0.55) | L3MBTL1HTR6AKR1C3AKR1C2ICMT | |
| SCHEMBL30458192 | 0.85 | HTR6 (0.55) | L3MBTL1HTR6AKR1C3AKR1C2ICMT | |
| SCHEMBL30458162 | 0.84 | HTR6 (0.54) | L3MBTL1HTR6AKR1C3AKR1C2ICMT | |
| SCHEMBL2018732 | 0.83 | L3MBTL1 (0.78) | L3MBTL1HTR6AKR1C3ALDH1A1MAPT | |
| SCHEMBL29651147 | 0.83 | L3MBTL1 (0.78) | L3MBTL1HTR6AKR1C3ALDH1A1MAPT | |
| SCHEMBL17871942 | 0.82 | L3MBTL1 (0.52) | L3MBTL1HTR6AKR1C3AKR1C2ALDH1A1 | |
| SCHEMBL14499879 | 0.81 | HTR6 (0.55) | L3MBTL1HTR6AKR1C3AKR1C2ICMT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2142516-B1 | PYRIMIDINE HYDRAZIDE COMPOUNDS AS PGDS INHIBITORS | SANOFI SA (FR) | 2012-12-26 | — | — | EP | disclosed |
| US-8258130-B2 | Pyrimidine hydrazide compounds as PGDS inhibitors | SANOFI (FR) | 2012-09-04 | — | — | US | disclosed |
| US-20100048568-A1 | PYRIMIDINE HYDRAZIDE COMPOUNDS AS PGDS INHIBITORS | SANOFI-AVENTIS (FR) | 2010-02-25 | — | — | US | disclosed |
| EP-2142516-A1 | PYRIMIDINE HYDRAZIDE COMPOUNDS AS PGDS INHIBITORS | Sanofi-Aventis (FR) | 2010-01-13 | — | — | EP | disclosed |
| WO-2008121670-A1 | PYRIMIDINE HYDRAZIDE COMPOUNDS AS PGDS INHIBITORS | SANOFI-AVENTIS (FR) | 2008-10-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100048568-A1 | PYRIMIDINE HYDRAZIDE COMPOUNDS AS PGDS INHIBITORS | HRH2, HRH1, HRH4 | L3MBTL1 3418/4885HTR6 609/4885AKR1C3 736/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.