Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.40 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.40 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.37 |
| ▸ | ICMT | O60725 | 1/20 | 0.36 |
| ▸ | ALB | P02768 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3227685 | 0.92 | SMN1; SMN2 (0.38) | SMN1; SMN2HDAC3HDAC1HDAC2HDAC10 | |
| SCHEMBL3225360 | 0.84 | SMN1; SMN2 (0.43) | SMN1; SMN2HDAC3HDAC1HDAC2HDAC10 | |
| SCHEMBL5597120 | 0.83 | SMN1; SMN2 (0.47) | SMN1; SMN2HDAC3HDAC1HDAC2HDAC10 | |
| SCHEMBL5596894 | 0.79 | MTNR1A (0.43) | SMN1; SMN2ALDH1A1HPGDMAPTNPSR1 | |
| SCHEMBL16741512 | 0.78 | SMN1; SMN2 (0.50) | SMN1; SMN2HDAC3HDAC1HDAC2HDAC10 | |
| SCHEMBL9162363 | 0.78 | GNAI3 (0.55) | SMN1; SMN2HDAC3HDAC1HDAC2HDAC10 | |
| SCHEMBL75816 | 0.76 | SMN1; SMN2 (0.40) | SMN1; SMN2HDAC3HDAC1HDAC2HDAC10 | |
| SCHEMBL3227797 | 0.75 | SIGMAR1 (0.51) | SMN1; SMN2ALDH1A1ATMMAPTKMT2A | |
| SCHEMBL7005369 | 0.73 | ALDH1A1 (0.43) | SMN1; SMN2ALDH1A1HPGDATMMAPT | |
| SCHEMBL5597078 | 0.73 | ALDH1A1 (0.43) | SMN1; SMN2ALDH1A1HPGDATMMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100063049-A1 | 2-CARBOCYCLOAMINO-4-IMIDAZOLYLPYRIMIDINES AS AGENTS FOR THE INHBITION OF CELL PROLIFERATION | ASTRAZENECA AB (SE) | 2010-03-11 | — | — | US | disclosed |
| CN-101454312-A | 2-Carbocyclic amino-4-imidazolyl pyrimidines as inhibitors of cell proliferation | ASTRAZENECA AB (SE) | 2009-06-10 | — | — | CN | disclosed |
| EP-2029578-A1 | 2-CARBOCYCLOAMINO-4-IMIDAZ0LYLPYRIMIDINES AS AGENTS FOR THE INHBITION OF CELL PROLIFERATION | AstraZeneca AB (SE) | 2009-03-04 | — | — | EP | disclosed |
| WO-2007138277-A1 | 2-CARBOCYCLOAMINO-4-IMIDAZ0LYLPYRIMIDINES AS AGENTS FOR THE INHBITION OF CELL PROLIFERATION | ASTRAZENECA AB (SE) | 2007-12-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100063049-A1 | 2-CARBOCYCLOAMINO-4-IMIDAZOLYLPYRIMIDINES AS AGENTS FOR THE INHBITION OF CELL PROLIFERATION | MKI67, CCNI, CDK2 | SMN1; SMN2 2839/4885HDAC3 1176/4885HDAC1 189/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.