Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 1/20 | 0.55 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.49 |
| ▸ | DPP4 | P27487 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | PREP | P48147 | 1/20 | 0.42 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.42 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.42 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.42 |
| ▸ | XIAP | P98170 | 2/20 | 0.40 |
| ▸ | BIRC2 | Q13490 | 2/20 | 0.40 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.39 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.39 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.38 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.38 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.38 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.37 |
| ▸ | ELANE | P08246 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12182668 | 0.84 | ALDH1A1 (0.44) | HTR2CHSD11B1DPP4ALDH1A1LMNA | |
| SCHEMBL12182701 | 0.84 | ALDH1A1 (0.44) | HTR2CHSD11B1DPP4ALDH1A1LMNA | |
| Hydrochloric Acid SCHEMBL28829935 | 0.83 | ALDH1A1 (0.46) | HTR2CHSD11B1DPP4ALDH1A1LMNA | |
| Hydrochloric Acid SCHEMBL28829934 | 0.83 | ALDH1A1 (0.46) | HTR2CHSD11B1DPP4ALDH1A1LMNA | |
| Hydrochloric Acid SCHEMBL29767487 | 0.83 | ALDH1A1 (0.46) | HTR2CHSD11B1DPP4ALDH1A1LMNA | |
| SCHEMBL3221802 | 0.82 | HSD11B1 (0.59) | HTR2CHSD11B1ALDH1A1LMNA | |
| SCHEMBL3219995 | 0.82 | HSD11B1 (0.59) | HTR2CHSD11B1ALDH1A1LMNA | |
| SCHEMBL20830204 | 0.82 | DRD2 (0.49) | HTR2CHSD11B1DPP4ALDH1A1PREP | |
| SCHEMBL6859247 | 0.81 | HSD11B1 (0.42) | HTR2CHSD11B1DPP4PREPDPP8 | |
| SCHEMBL6859245 | 0.81 | HSD11B1 (0.42) | HTR2CHSD11B1DPP4PREPDPP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010141550-A2 | 11-BETA HSD1 INHIBITORS | WYETH LLC (US) | 2010-12-09 | — | — | WO | disclosed |
| US-20100029648-A1 | 11-Beta HSD1 Inhibitors | XIANG JASON SHAOYUN | 2010-02-04 | — | — | US | disclosed |
| US-7632838-B2 | 11-beta HSD1 inhibitors | WYETH (US) | 2009-12-15 | — | — | US | disclosed |
| US-20070219198-A1 | 11-Beta HSD 1 inhibitors | WYETH (US) | 2007-09-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100029648-A1 | 11-Beta HSD1 Inhibitors | HSD11B1, HSD3B1, HSD11B2 | HTR2C 1366/4885HSD11B1 1/4885DPP4 310/4885 |
| US-20070219198-A1 | 11-Beta HSD 1 inhibitors | HSD11B1, HSD11B2, HSD3B1 | HTR2C 806/4885HSD11B1 1/4885DPP4 288/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.