Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.74 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.63 |
| ▸ | MBTD1 | Q05BQ5 | 1/20 | 0.61 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.61 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.59 |
| ▸ | NCF1 | P14598 | 1/20 | 0.57 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | DRD4 | P21917 | 1/20 | 0.55 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.55 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.55 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1888525 | 0.98 | HRH3 (0.78) | HRH3HRH4ALDH1A1KDM4EMBTD1 | |
| Methane SCHEMBL8063684 | 0.96 | HRH3 (0.75) | HRH3HRH4ALDH1A1KDM4EMBTD1 | |
| SCHEMBL5428090 | 0.91 | DRD4 (0.63) | HRH3HRH4ALDH1A1KDM4EPOLB | |
| SCHEMBL11201497 | 0.88 | HRH3 (0.94) | HRH3HRH4ALDH1A1KDM4EMBTD1 | |
| Hydrochloric Acid SCHEMBL11196296 | 0.85 | HRH3 (0.90) | HRH3HRH4ALDH1A1KDM4EMBTD1 | |
| SCHEMBL4277270 | 0.85 | HRH3 (1.00) | HRH3HRH4ALDH1A1KDM4EMBTD1 | |
| Hydrochloric Acid SCHEMBL7468055 | 0.83 | HRH3 (0.95) | HRH3HRH4ALDH1A1KDM4EMBTD1 | |
| SCHEMBL9720752 | 0.83 | DRD4 (0.77) | POLBDRD4 | |
| SCHEMBL8804975 | 0.83 | DRD4 (0.51) | HRH3HRH4ALDH1A1KDM4ECXCR4 | |
| SCHEMBL2250410 | 0.82 | HRH3 (0.74) | HRH3HRH4ALDH1A1KDM4EMBTD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 68 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115515955-A | Crystalline forms of 4- [ (7-chloro-2-methoxybenzo [ b ] [1,5] naphthyridin-10-yl) amino ] -2, 6-bis (pyrrolidin-1-ylmethyl) phenol and salts thereof | 默克专利股份公司 | 2022-12-23 | — | — | CN | claimed |
| US-7196104-B2 | Thiazolyl urea compounds and methods of uses | AMGEN, INC. (US) | 2007-03-27 | — | — | US | claimed |
| EP-1483263-A1 | THIAZOLYL UREA COMPOUNDS FOR THE TREATMENT OF CANCER | Amgen Inc. (US) | 2004-12-08 | — | — | EP | claimed |
| US-20040044044-A1 | Thiazolyl urea compounds and methods of uses | AMGEN INC. | 2004-03-04 | — | — | US | claimed |
| US-20040039029-A1 | Thiazolyl urea compounds and methods of uses | AMGEN INC. | 2004-02-26 | — | — | US | claimed |
| US-6645990-B2 | For prophylaxis and therapy of diseases, such as cell proliferation or apoptosis mediated diseases | AMGEN INC. | 2003-11-11 | — | — | US | claimed |
| WO-2003070727-A1 | THIAZOLYL UREA COMPOUNDS FOR THE TREATMENT OF CANCER | AMGEN INC. (US) | 2003-08-28 | — | — | WO | claimed |
| US-20020193405-A1 | Thiazolyl urea compounds and methods of uses | AMGEN INC. | 2002-12-19 | — | — | US | claimed |
| WO-2024135186-A1 | PHOTOSENSITIVE RESIN COMPOSITION, CURED PRODUCT, ORGANIC EL DISPLAY DEVICE, DISPLAY DEVICE, AND PHENOL COMPOUND | 東レ株式会社 | 2024-06-27 | — | — | WO | disclosed |
| CN-115515955-A | Crystalline forms of 4- [ (7-chloro-2-methoxybenzo [ b ] [1,5] naphthyridin-10-yl) amino ] -2, 6-bis (pyrrolidin-1-ylmethyl) phenol and salts thereof | 默克专利股份公司 | 2022-12-23 | — | — | CN | disclosed |
| CN-115515955-A | Crystalline forms of 4- [ (7-chloro-2-methoxybenzo [ b ] [1,5] naphthyridin-10-yl) amino ] -2, 6-bis (pyrrolidin-1-ylmethyl) phenol and salts thereof | 默克专利股份公司 | 2022-12-23 | — | — | CN | disclosed |
| CN-115515955-A | Crystalline forms of 4- [ (7-chloro-2-methoxybenzo [ b ] [1,5] naphthyridin-10-yl) amino ] -2, 6-bis (pyrrolidin-1-ylmethyl) phenol and salts thereof | 默克专利股份公司 | 2022-12-23 | — | — | CN | disclosed |
| US-20220204472-A1 | HETEROAROMATIC ELECTROPHILES AND METHODS OF USING THEREOF | OHIO STATE INNOVATION FOUNDATION | 2022-06-30 | — | — | US | disclosed |
| CN-114569552-A | Anti-malarial compositions and uses thereof | 斯克利普斯研究院 | 2022-06-03 | — | — | CN | disclosed |
| US-6638967-B2 | Pyrrole, furan, thiofuran and phenyl derivatives; inhibition of histamine H3 receptor activity; for example, 1-((4-(4-Pyrrolidin-1-ylmethyl-phenyl)-thien-2-yl)methyl)-pyrrolidine | ORTHO-MCNEIL PHAMRACEUTICAL, INC. | 2003-10-28 | — | — | US | disclosed |
| WO-2003070727-A1 | THIAZOLYL UREA COMPOUNDS FOR THE TREATMENT OF CANCER | AMGEN INC. (US) | 2003-08-28 | — | — | WO | disclosed |
| EP-1311499-A2 | BICYCLIC COMPOUNDS AS H3 RECEPTOR LIGANDS | Ortho-McNeil Pharmaceutical, Inc. (US) | 2003-05-21 | — | — | EP | disclosed |
| US-20020193405-A1 | Thiazolyl urea compounds and methods of uses | AMGEN INC. | 2002-12-19 | — | — | US | disclosed |
| US-20020037896-A1 | Pyrrole, furan, thiofuran and phenyl derivatives; inhibition of histamine H3 receptor activity; for example, 1-((4-(4-Pyrrolidin-1-ylmethyl-phenyl)-thien-2-yl)methyl)-pyrrolidine | ORTHO MCNEIL PHARMACEUTICAL, INC. | 2002-03-28 | — | — | US | disclosed |
| WO-2002012224-A2 | BICYCLIC COMPOUNDS AS H3 RECEPTOR LIGANDS | ORTHO MCNEIL PHARMACEUTICAL, INC. (US) | 2002-02-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020193405-A1 | Thiazolyl urea compounds and methods of uses | SLC14A1, UMPS, BAX | HRH3 3754/4885HRH4 2873/4885ALDH1A1 810/4885 |
| US-20220204472-A1 | HETEROAROMATIC ELECTROPHILES AND METHODS OF USING THEREOF | ACHE, BCHE, CHAT | HRH3 470/4885HRH4 801/4885ALDH1A1 1025/4885 |
| US-20020037896-A1 | Pyrrole, furan, thiofuran and phenyl derivatives; inhibition of histamine H3 receptor activity; for example, 1-((4-(4-Pyrrolidin-1-ylmethyl-phenyl)-thien-2-yl)methyl)-pyrrolidine | HRH4, HRH3, HRH2 | HRH3 2/4885HRH4 1/4885ALDH1A1 1225/4885 |
| US-20040039029-A1 | Thiazolyl urea compounds and methods of uses | SLC14A1, UMPS, BAX | HRH3 3754/4885HRH4 2873/4885ALDH1A1 810/4885 |
| US-20040044044-A1 | Thiazolyl urea compounds and methods of uses | SLC14A1, UMPS, BAX | HRH3 3754/4885HRH4 2873/4885ALDH1A1 810/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.