Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES1 | P23141 | 1/20 | 0.57 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.55 |
| ▸ | SIGMAR1 | Q99720 | 6/20 | 0.44 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.43 |
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
| ▸ | LTB4R | Q15722 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6657646 | 0.87 | PDPK1 (0.48) | CES1PLA2G4APDPK1SLC6A3SMN1; SMN2 | |
| SCHEMBL30292850 | 0.81 | TDP1 (0.56) | L3MBTL1CYP2D6 | |
| SCHEMBL22398125 | 0.81 | ESR1 (0.46) | CES1PLA2G4ASLC6A3 | |
| SCHEMBL7447763 | 0.79 | SIGMAR1 (0.53) | CES1PLA2G4ASIGMAR1HPGD | |
| Thiourea SCHEMBL5173435 | 0.78 | PLA2G4A (0.44) | CES1PLA2G4APDPK1SLC6A3SMN1; SMN2 | |
| SCHEMBL378027 | 0.77 | PDPK1 (0.50) | CES1PLA2G4APDPK1SLC6A3SMN1; SMN2 | |
| SCHEMBL18956313 | 0.76 | PLA2G4A (0.59) | CES1PLA2G4ASMN1; SMN2L3MBTL1HPGD | |
| SCHEMBL627047 | 0.76 | HRH1 (0.43) | — | |
| SCHEMBL7275156 | 0.76 | FDPS (0.41) | CES1PLA2G4ASIGMAR1SLC6A3CYP2D6 | |
| SCHEMBL6061151 | 0.76 | FDPS (0.37) | CES1PLA2G4ASIGMAR1SLC6A3CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010005572-A2 | ALPHA-KETO HETEROCYCLES AS FAAH INHIBITORS | THE SCRIPPS RESEARCH INSTITUTE (US) | 2010-01-14 | — | — | WO | disclosed |