Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.36 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.36 |
| ▸ | PFKFB3 | Q16875 | 3/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | CMA1 | P23946 | 3/20 | 0.34 |
| ▸ | PFKFB4 | Q16877 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL337593 | 0.75 | NPSR1 (0.62) | NPSR1L3MBTL1KDM4EAKR1B1PFKFB3 | |
| SCHEMBL788639 | 0.75 | NPSR1 (0.48) | NPSR1L3MBTL1AKR1B1PFKFB3CMA1 | |
| SCHEMBL3689324 | 0.71 | KDM4E (0.46) | NPSR1L3MBTL1KDM4EAKR1B1CYP2A6 | |
| SCHEMBL7472162 | 0.68 | NPSR1 (0.45) | NPSR1L3MBTL1KDM4EAKR1B1CYP2A6 | |
| SCHEMBL7539216 | 0.68 | NPSR1 (0.45) | NPSR1L3MBTL1KDM4EAKR1B1PFKFB3 | |
| SCHEMBL3686803 | 0.68 | KDM4E (0.46) | NPSR1L3MBTL1KDM4EAKR1B1CYP2A6 | |
| SCHEMBL11060333 | 0.66 | PTGDR2 (0.50) | L3MBTL1KDM4ECYP1A2HPGD | |
| SCHEMBL3224597 | 0.66 | CYP2A6 (0.43) | NPSR1L3MBTL1TRPV4KDM4ECYP2A6 | |
| SCHEMBL3683337 | 0.65 | KDM4E (0.43) | NPSR1L3MBTL1KDM4EAKR1B1PFKFB3 | |
| SCHEMBL3947527 | 0.64 | HTR6 (0.45) | NPSR1L3MBTL1KDM4EAKR1B1CYP2A6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100029648-A1 | 11-Beta HSD1 Inhibitors | XIANG JASON SHAOYUN | 2010-02-04 | — | — | US | disclosed |
| US-7632838-B2 | 11-beta HSD1 inhibitors | WYETH (US) | 2009-12-15 | — | — | US | disclosed |
| EP-1981848-A2 | 11-BETA HSD1 INHIBITORS | Wyeth (US) | 2008-10-22 | — | — | EP | disclosed |
| US-20070219198-A1 | 11-Beta HSD 1 inhibitors | WYETH (US) | 2007-09-20 | — | — | US | disclosed |
| WO-2007092435-A2 | 11-BETA HSD1 INHIBITORS | WYETH (US) | 2007-08-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100029648-A1 | 11-Beta HSD1 Inhibitors | HSD11B1, HSD3B1, HSD11B2 | NPSR1 2139/4885L3MBTL1 1721/4885TRPV4 4751/4885 |
| US-20070219198-A1 | 11-Beta HSD 1 inhibitors | HSD11B1, HSD11B2, HSD3B1 | NPSR1 1342/4885L3MBTL1 2300/4885TRPV4 4618/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.