Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 1.00 |
| ▸ | MMP1 | P03956 | 4/20 | 0.71 |
| ▸ | MMP2 | P08253 | 4/20 | 0.71 |
| ▸ | MMP9 | P14780 | 4/20 | 0.71 |
| ▸ | EGFR | P00533 | 1/20 | 0.71 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.69 |
| ▸ | PKM | P14618 | 2/20 | 0.69 |
| ▸ | MAPT | P10636 | 1/20 | 0.69 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.66 |
| ▸ | HPGD | P15428 | 3/20 | 0.63 |
| ▸ | MEN1 | O00255 | 1/20 | 0.63 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.63 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.62 |
| ▸ | LPAR3 | Q9UBY5 | 1/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.59 |
| ▸ | LMNA | P02545 | 2/20 | 0.59 |
| ▸ | HTT | P42858 | 3/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.59 |
| ▸ | NPC1 | O15118 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3224656 | 1.00 | ALDH1A1 (1.00) | ALDH1A1MMP1MMP2MMP9EGFR | |
| SCHEMBL11140025 | 0.87 | KDM4E (0.81) | ALDH1A1KDM4EPKMMAPTHPGD | |
| SCHEMBL11140030 | 0.87 | KDM4E (0.81) | ALDH1A1KDM4EPKMMAPTHPGD | |
| SCHEMBL25078269 | 0.83 | ALDH1A1 (0.71) | ALDH1A1MMP1MMP2MMP9EGFR | |
| N-(2-Fluorophenyl)Cinnamamide SCHEMBL1967607 | 0.83 | MMP1 (1.00) | ALDH1A1MMP1MMP2MMP9EGFR | |
| N-(2-Fluorophenyl)Cinnamamide SCHEMBL1967609 | 0.83 | MMP1 (1.00) | ALDH1A1MMP1MMP2MMP9EGFR | |
| SCHEMBL6546826 | 0.82 | ALDH1A1 (0.70) | ALDH1A1KDM4EPKMMAPTCYP2C19 | |
| SCHEMBL10252792 | 0.82 | ALDH1A1 (0.70) | ALDH1A1KDM4EPKMMAPTCYP2C19 | |
| SCHEMBL6546829 | 0.82 | ALDH1A1 (0.70) | ALDH1A1KDM4EPKMMAPTCYP2C19 | |
| SCHEMBL5176156 | 0.80 | KDM4E (0.77) | ALDH1A1MMP1MMP2MMP9KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100279963-A1 | DICARBONYL DERIVATIVES AND METHODS OF USE | ABRAXIS BIOSCIENCE, LLC (US) | 2010-11-04 | — | — | US | disclosed |
| US-7799954-B2 | Dicarbonyl derivatives and methods of use | ABRAXIS BIOSCIENCE, LLC (US) | 2010-09-21 | — | — | US | disclosed |
| EP-2125694-A2 | DICARBONYL DERIVATIVES AND METHODS OF USE | Abraxis BioScience, Inc. (US) | 2009-12-02 | — | — | EP | disclosed |
| US-20080146586-A1 | DICARBONYL DERIVATIVES AND METHODS OF USE | ABRAXIS BIOSCIENCE (US) | 2008-06-19 | — | — | US | disclosed |
| WO-2008064060-A2 | DICARBONYL DERIVATIVES AND METHODS OF USE | ABRAXIS BIOSCIENCE, INC. (US) | 2008-05-29 | — | — | WO | disclosed |
| EP-1091958-A1 | SALTS OF PAROXETINE | SMITHKLINE BEECHAM PLC (GB) | 2001-04-18 | — | — | EP | disclosed |
| WO-2000001692-A1 | SALTS OF PAROXETINE | SMITHKLINE BEECHAM PLC (GB) | 2000-01-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080146586-A1 | DICARBONYL DERIVATIVES AND METHODS OF USE | AADAC, DCK, MLYCD | ALDH1A1 1688/4885MMP1 2536/4885MMP2 886/4885 |
| US-20100279963-A1 | DICARBONYL DERIVATIVES AND METHODS OF USE | AADAC, DCK, MLYCD | ALDH1A1 1688/4885MMP1 2536/4885MMP2 886/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.