Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Sorbitol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.69 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.69 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.65 |
| ▸ | PDE4A | P27815 | 1/20 | 0.52 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | CA5A | P35218 | 1/20 | 0.38 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | MGAM | O43451 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
| ▸ | TOP1 | P11387 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Mannitol SCHEMBL3887158 | 1.00 | LMNA (0.69) | LMNAL3MBTL1TDP1PDE4AUSP2 | |
| Mannitol SCHEMBL20572201 | 1.00 | LMNA (0.69) | LMNAL3MBTL1TDP1PDE4AUSP2 | |
| Mannitol SCHEMBL29080611 | 0.97 | LMNA (0.65) | LMNAL3MBTL1TDP1PDE4AUSP2 | |
| Sorbitol SCHEMBL628565 | 0.97 | LMNA (0.65) | LMNAL3MBTL1TDP1PDE4AUSP2 | |
| Sorbitol SCHEMBL15993963 | 0.97 | LMNA (0.65) | LMNAL3MBTL1TDP1PDE4AUSP2 | |
| Mannitol SCHEMBL29080612 | 0.97 | LMNA (0.65) | LMNAL3MBTL1TDP1PDE4AUSP2 | |
| Adonitol SCHEMBL20481269 | 0.94 | LMNA (0.59) | LMNAL3MBTL1TDP1PDE4AUSP2 | |
| Mannitol SCHEMBL31109182 | 0.92 | PDE4A (0.58) | LMNAL3MBTL1TDP1PDE4AUSP2 | |
| Mannitol SCHEMBL7249316 | 0.88 | LMNA (0.61) | LMNAL3MBTL1TDP1PDE4AUSP2 | |
| Sulfuric Acid SCHEMBL23754263 | 0.87 | LMNA (0.52) | LMNAL3MBTL1TDP1PDE4AUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-62215510-A | — | — | None | — | — | JP | disclosed |
| JP-8081351-A | — | — | None | — | — | JP | disclosed |
| US-20240189398-A1 | LIQUID COMPOSITION COMPRISING FACTOR VIII OR FACTOR VIII/VON WILLEBRAND FACTOR COMPLEX | GRIFOLS WORLDWIDE OPERATIONS LIMITED (IE) | 2024-06-13 | — | — | US | disclosed |
| EP-4322918-A1 | LIQUID COMPOSITION COMPRISING FACTOR VIII OR FACTOR VIII/VON WILLEBRAND FACTOR COMPLEX | Grifols Worldwide Operations Limited (IE) | 2024-02-21 | — | — | EP | disclosed |
| CN-117136046-A | Liquid composition comprising factor VIII or factor VIII/von willebrand factor complex | 基立福环球运营有限公司 | 2023-11-28 | — | — | CN | disclosed |
| WO-2023160616-A1 | A HYDROGEL COMPOSITION FOR PREPARING CUSTOMIZED MASK PACK | BASF SE (DE) | 2023-08-31 | — | — | WO | disclosed |
| US-20100062029-A1 | Product for the Targeted Release of Active Substances | LTS LOHMANN THERAPIE-SYSTEME AG (DE) | 2010-03-11 | — | — | US | disclosed |
| US-20080145388-A1 | cosmetic cleaning product for controlling release; two layers define a compartment between them, which contains the active substance and optionally a gas-releasing component; one is impermeable, and one is permeable to the active substance; single use for body care; glove shape | LTS LOHMANN THERAPIE-SYSTEME AG (DE) | 2008-06-19 | — | — | US | disclosed |
| US-20060052263-A1 | Soap preparation with air bubbles | SCS SKIN CARE SYSTEMS GMBH | 2006-03-09 | — | — | US | disclosed |
| CN-1192780-C | Therapeutical agent | TAKARA SHUZO CO (JP) | 2005-03-16 | — | — | CN | disclosed |
| CN-1355703-A | Therapeutical agent | TAKARA SHUZO CO (JP) | 2002-06-26 | — | — | CN | disclosed |
| EP-1175907-A1 | REMEDIES | Takara Shuzo Co, Ltd. (JP) | 2002-01-30 | — | — | EP | disclosed |
| WO-1999007339-A1 | COMPOSITIONS FOR VISUALLY IMPROVING SKIN | THE PROCTER & GAMBLE COMPANY (US) | 1999-02-18 | — | — | WO | disclosed |
| JP-H0881351-A | CUTICLE KERATINIZATION PROMOTING AGENT | KANEBO LTD | 1996-03-26 | — | — | JP | disclosed |
| JP-S62215510-A | EMULSIFIED COMPOSITION | SHISEIDO CO LTD | 1987-09-22 | — | — | JP | disclosed |