Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Sorbitol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.65 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.65 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.61 |
| ▸ | PDE4A | P27815 | 1/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | CA5A | P35218 | 1/20 | 0.35 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.35 |
| ▸ | MGAM | O43451 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.31 |
| ▸ | TOP1 | P11387 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Mannitol SCHEMBL20572201 | 0.97 | LMNA (0.69) | LMNAL3MBTL1TDP1PDE4AUSP2 | |
| Sorbitol SCHEMBL3227835 | 0.97 | LMNA (0.69) | LMNAL3MBTL1TDP1PDE4AUSP2 | |
| Mannitol SCHEMBL3887158 | 0.97 | LMNA (0.69) | LMNAL3MBTL1TDP1PDE4AUSP2 | |
| Mannitol SCHEMBL29080611 | 0.94 | LMNA (0.65) | LMNAL3MBTL1TDP1PDE4AUSP2 | |
| Sorbitol SCHEMBL15993963 | 0.94 | LMNA (0.65) | LMNAL3MBTL1TDP1PDE4AUSP2 | |
| Mannitol SCHEMBL29080612 | 0.94 | LMNA (0.65) | LMNAL3MBTL1TDP1PDE4AUSP2 | |
| Adonitol SCHEMBL20481269 | 0.91 | LMNA (0.59) | LMNAL3MBTL1TDP1PDE4AUSP2 | |
| Mannitol SCHEMBL31109182 | 0.89 | PDE4A (0.58) | LMNAL3MBTL1TDP1PDE4AUSP2 | |
| Mannitol SCHEMBL7249316 | 0.86 | LMNA (0.61) | LMNAL3MBTL1TDP1PDE4AUSP2 | |
| Sulfuric Acid SCHEMBL23754263 | 0.85 | LMNA (0.52) | LMNAL3MBTL1TDP1PDE4AUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 87 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-59117547-A | — | — | None | — | — | JP | disclosed |
| EP-4122443-B1 | COSMETIC COMPOSITION WITH SILICONE-MODIFIED POLYSACCHARIDE | SHINETSU CHEMICAL CO (JP) | 2026-05-06 | — | — | EP | disclosed |
| US-12539266-B2 | Cosmetic composition | SHIN-ETSU CHEMICAL CO., LTD. (JP) | 2026-02-03 | — | — | US | disclosed |
| EP-3699183-B1 | COSMETIC COMPRISING A UREA GROUP-CONTAINING ORGANOPOLYSILOXANE | SHINETSU CHEMICAL CO (JP) | 2024-07-24 | — | — | EP | disclosed |
| US-20230157942-A1 | COSMETIC | SHIN-ETSU CHEMICAL CO., LTD. (JP) | 2023-05-25 | — | — | US | disclosed |
| EP-3492514-B1 | NOVEL SILICONE COMPOUND AND COSMETIC CONTAINING SAME | SHINETSU CHEMICAL CO (JP) | 2023-05-10 | — | — | EP | disclosed |
| US-20230106469-A1 | COSMETIC COMPOSITION | SHIN-ETSU CHEMICAL CO., LTD. (JP) | 2023-04-06 | — | — | US | disclosed |
| EP-4122443-A1 | COSMETIC COMPOSITION | SHIN-ETSU CHEMICAL CO., LTD. (JP) | 2023-01-25 | — | — | EP | disclosed |
| EP-4112126-A1 | COSMETIC | Shin-Etsu Chemical Co., Ltd. (JP) | 2023-01-04 | — | — | EP | disclosed |
| US-11033481-B2 | Silicone resin, making method, and cosmetics | SHIN-ETSU CHEMICAL CO., LTD. (JP) | 2021-06-15 | — | — | US | disclosed |
| US-6784271-B2 | ADDITION REACTION BETWEEN A HYDROGEN SILOXANE AND A COMPOUND WITH A TERMINAL DOUBLE BOND IN THE PRESENCE OF A PLATINUM CATALYST | SHIN-ETSU CHEMICAL CO., LTD. (JP) | 2004-08-31 | — | — | US | disclosed |
| EP-1424373-A2 | Hydrophilized powder and a composition comprising the same | Shin-Etsu Chemical Company, Ltd. (JP) | 2004-06-02 | — | — | EP | disclosed |
| US-6576623-B1 | Compound or polymer containing siloxane and oxyalkylene groups; nonoily; spreads easily and smoothly; moist, fresh, dry feel; storage and heat stability | SHIN-ETSU CHEMICAL CO., LTD. (JP) | 2003-06-10 | — | — | US | disclosed |
| EP-1072627-B1 | Silicone compound and cosmetic materials containing the same | SHINETSU CHEMICAL CO (JP) | 2003-03-19 | — | — | EP | disclosed |
| EP-1291376-A1 | SILICONE POLYMER, SILICONE COMPOSITION, AND COSMETIC PREPARATION CONTAINING THE SAME | SHIN-ETSU CHEMICAL CO., LTD. (JP) | 2003-03-12 | — | — | EP | disclosed |
| EP-1291377-A1 | SILICONE COMPOUND AND COSMETIC PREPARATION | SHIN-ETSU CHEMICAL CO., LTD. (JP) | 2003-03-12 | — | — | EP | disclosed |
| EP-1213006-A1 | COSMETICS | KANEBO, LTD. (JP) | 2002-06-12 | — | — | EP | disclosed |
| EP-1213011-A1 | Cosmetic material comprising branched silicone compounds | SHIN-ETSU CHEMICAL CO., LTD. (JP) | 2002-06-12 | — | — | EP | disclosed |
| EP-1072627-A2 | Silicone compound and cosmetic materials containing the same | SHIN-ETSU CHEMICAL CO., LTD. (JP) | 2001-01-31 | — | — | EP | disclosed |
| JP-S59117547-A | GELATINOUS COMPOSITION | SHISEIDO CO LTD | 1984-07-06 | — | — | JP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230106469-A1 | COSMETIC COMPOSITION | CUTA, CD44, ALG1 | LMNA 2430/4885L3MBTL1 3804/4885TDP1 1133/4885 |
| US-12539266-B2 | Cosmetic composition | CUTA, FSCN1, FUCA1 | LMNA 1254/4885L3MBTL1 2351/4885TDP1 2044/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.