Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Mannitol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.69 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.69 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.65 |
| ▸ | PDE4A | P27815 | 1/20 | 0.52 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | CA5A | P35218 | 1/20 | 0.38 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | MGAM | O43451 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
| ▸ | TOP1 | P11387 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Sorbitol SCHEMBL3227835 | 1.00 | LMNA (0.69) | LMNAL3MBTL1TDP1PDE4AUSP2 | |
| Mannitol SCHEMBL20572201 | 1.00 | LMNA (0.69) | LMNAL3MBTL1TDP1PDE4AUSP2 | |
| Mannitol SCHEMBL29080611 | 0.97 | LMNA (0.65) | LMNAL3MBTL1TDP1PDE4AUSP2 | |
| Sorbitol SCHEMBL628565 | 0.97 | LMNA (0.65) | LMNAL3MBTL1TDP1PDE4AUSP2 | |
| Sorbitol SCHEMBL15993963 | 0.97 | LMNA (0.65) | LMNAL3MBTL1TDP1PDE4AUSP2 | |
| Mannitol SCHEMBL29080612 | 0.97 | LMNA (0.65) | LMNAL3MBTL1TDP1PDE4AUSP2 | |
| Adonitol SCHEMBL20481269 | 0.94 | LMNA (0.59) | LMNAL3MBTL1TDP1PDE4AUSP2 | |
| Mannitol SCHEMBL31109182 | 0.92 | PDE4A (0.58) | LMNAL3MBTL1TDP1PDE4AUSP2 | |
| Mannitol SCHEMBL7249316 | 0.88 | LMNA (0.61) | LMNAL3MBTL1TDP1PDE4AUSP2 | |
| Sulfuric Acid SCHEMBL23754263 | 0.87 | LMNA (0.52) | LMNAL3MBTL1TDP1PDE4AUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108948641-B | Mannitol sulfate modified heat-resistant ABS engineering plastic | 义乌市力天电器有限公司 | 2020-11-17 | — | — | CN | claimed |
| EP-2012802-B1 | NOVEL DRUGS FOR ANTI-HERPES VIRUS TREATMENTS | ASE & BIO (FR) | 2012-08-29 | — | — | EP | claimed |
| EP-2012802-A1 | NOVEL DRUGS FOR ANTI-HERPES VIRUS TREATMENTS | Laboratoire de la Mer (FR) | 2009-01-14 | — | — | EP | claimed |
| EP-2007400-A1 | NEW MEDICINES FOR TREATMENTS AGAINST RETROVIRUSES | Laboratoire de la Mer (FR) | 2008-12-31 | — | — | EP | claimed |
| WO-2007128914-A1 | NOVEL DRUGS FOR ANTI-HERPES VIRUS TREATMENTS | LABORATOIRE DE LA MER (FR) | 2007-11-15 | — | — | WO | claimed |
| WO-2007119006-A1 | NEW MEDICINES FOR TREATMENTS AGAINST RETROVIRUSES | LABORATOIRE DE LA MER (FR) | 2007-10-25 | — | — | WO | claimed |
| CN-118717944-A | Composition containing polymyxin B sulfate, preparation method, freeze-dried powder, injection medicine and application of composition | 成都倍特药业股份有限公司 | 2024-10-01 | — | — | CN | disclosed |
| EP-4284344-A1 | PHARMACEUTICAL COMPOSITION | Novartis AG (CH) | 2023-12-06 | — | — | EP | disclosed |
| CN-108948641-B | Mannitol sulfate modified heat-resistant ABS engineering plastic | 义乌市力天电器有限公司 | 2020-11-17 | — | — | CN | disclosed |
| CN-108948641-B | Mannitol sulfate modified heat-resistant ABS engineering plastic | 义乌市力天电器有限公司 | 2020-11-17 | — | — | CN | disclosed |
| EP-2012802-B1 | NOVEL DRUGS FOR ANTI-HERPES VIRUS TREATMENTS | ASE & BIO (FR) | 2012-08-29 | — | — | EP | disclosed |
| EP-2012802-A1 | NOVEL DRUGS FOR ANTI-HERPES VIRUS TREATMENTS | Laboratoire de la Mer (FR) | 2009-01-14 | — | — | EP | disclosed |
| EP-2007400-A1 | NEW MEDICINES FOR TREATMENTS AGAINST RETROVIRUSES | Laboratoire de la Mer (FR) | 2008-12-31 | — | — | EP | disclosed |
| WO-2007128914-A1 | NOVEL DRUGS FOR ANTI-HERPES VIRUS TREATMENTS | LABORATOIRE DE LA MER (FR) | 2007-11-15 | — | — | WO | disclosed |
| WO-2007119006-A1 | NEW MEDICINES FOR TREATMENTS AGAINST RETROVIRUSES | LABORATOIRE DE LA MER (FR) | 2007-10-25 | — | — | WO | disclosed |