Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Acetic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR3 | O14843 | 3/20 | 0.50 |
| ▸ | LCK | P06239 | 1/20 | 0.50 |
| ▸ | FYN | P06241 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 3/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | SLC15A2 | Q16348 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.32 |
| ▸ | THPO | P40225 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Carbamic Acid SCHEMBL21986555 | 0.83 | ACHE (0.47) | FFAR3ALDH1A1TDP1CYP2D6CYP2C19 | |
| Diethyl Sulfide SCHEMBL8751214 | 0.79 | — | — | |
| Acetic Acid SCHEMBL9051977 | 0.76 | — | — | |
| Acetic Acid SCHEMBL5837058 | 0.76 | FFAR3 (0.70) | FFAR3LCKFYNALDH1A1TDP1 | |
| Acetic Acid SCHEMBL8736141 | 0.76 | FFAR3 (0.70) | FFAR3LCKFYNALDH1A1TDP1 | |
| SCHEMBL82321 | 0.76 | — | — | |
| Acetic Acid SCHEMBL3782093 | 0.72 | FFAR3 (0.64) | FFAR3LCKFYNALDH1A1TDP1 | |
| Acetic Acid SCHEMBL6517807 | 0.72 | FFAR3 (0.64) | FFAR3LCKFYNALDH1A1TDP1 | |
| Acetic Acid SCHEMBL6290880 | 0.72 | FFAR3 (0.64) | FFAR3LCKFYNALDH1A1TDP1 | |
| Acetic Acid SCHEMBL3359645 | 0.72 | FFAR3 (0.64) | FFAR3LCKFYNALDH1A1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103635547-B | Cationic electrodeposition coating composition capable of being applied to narrow gap portions and electrodeposition coating film forming method using same | 日产自动车株式会社 | 2017-03-08 | — | — | CN | disclosed |
| CN-105358602-A | Modified resin and resin composition | ASAHI KASEI CHEMICALS CORP | 2016-02-24 | — | — | CN | disclosed |
| CN-103635547-A | Cationic electrodeposition coating composition capable of being applied to narrow gap portions and electrodeposition coating film forming method using same | NISSAN MOTOR | 2014-03-12 | — | — | CN | disclosed |
| US-20100273004-A1 | MULTI-LAYER COATING FILM STRUCTURE | MAZDA MOTOR CORPORATION (JP) | 2010-10-28 | — | — | US | disclosed |
| EP-2243560-A2 | Multi-layer coating film structure | Mazda Motor Corporation (JP) | 2010-10-27 | — | — | EP | disclosed |
| US-20060201821-A1 | Method for forming electrodeposited coating | NIPPON PAINT CO., LTD. (JP) | 2006-09-14 | — | — | US | disclosed |
| US-20050161330-A1 | Process for forming multi layered coated film and multi layered coated film | NIPPON PAINT CO., LTD. (JP) | 2005-07-28 | — | — | US | disclosed |
| US-5770642-A | CORROSION RESISTANCE WITHOUT LEAD PIGMENTS, EPOXY RESIN WITH OXAZOLIDONE GROUP CROSSLINKED WITH BLOCKED DIISOCYANATE | NIPPON PAINT CO., LTD. (JP) | 1998-06-23 | — | — | US | disclosed |
| US-5744521-A | COMPRISING A CATIONICALLY MODIFIED EPOXY RESIN AND A CROSSLINKER DISPERSED IN AN AQUEOUS MEDIUM CONTAINING A NEUTRALIZING ACID | NIPPON PAINT CO., LTD. (JP) | 1998-04-28 | — | — | US | disclosed |