Sugi Predict

Sugi Predict / Compounds / SCHEMBL3229641

SCHEMBL3229641

SCHEMBL3229641

CC1=C(C(N)=O)c2cc(Cl)ccc2[N]1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 2/20 0.41
▸ KDM4E B2RXH2 1/20 0.41
▸ GLA P06280 1/20 0.41
▸ GAA P10253 1/20 0.41
▸ PARP1 P09874 1/20 0.40
▸ SLC9A1 P19634 4/20 0.38
▸ JAK2 O60674 6/20 0.38
▸ GRM2 Q14416 2/20 0.37
▸ DPP4 P27487 1/20 0.37
▸ DPP8 Q6V1X1 1/20 0.37
▸ FGFR1 P11362 1/20 0.35
▸ SRC P12931 1/20 0.35
▸ FGFR2 P21802 1/20 0.35
▸ FGFR4 P22455 1/20 0.35
▸ FGFR3 P22607 1/20 0.35
▸ HPGD P15428 1/20 0.35
▸ RAB9A P51151 1/20 0.35
▸ SMN1; SMN2 Q16637 1/20 0.35
▸ ADRA1D P25100 1/20 0.35
▸ MAP2 P11137 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3220219 0.81 SLC9A1 (0.39) ALDH1A1KDM4EPARP1SLC9A1GRM2
SCHEMBL14743082 0.68 S100A4 (0.44) ALDH1A1HPGDSMN1; SMN2
SCHEMBL1999332 0.66 ALDH1A1 (0.59) ALDH1A1KDM4EGLAGAAPARP1
SCHEMBL3790275 0.63 ALDH1A1 (0.60) ALDH1A1KDM4EGLAGAAPARP1
SCHEMBL4963407 0.62 S100A4 (0.50) ALDH1A1PARP1
SCHEMBL2468739 0.62 KDM4E (0.55) ALDH1A1KDM4EGLAGAAHPGD
SCHEMBL8561883 0.62 KDM4E (0.50) ALDH1A1KDM4EGLAGAAGRM2
SCHEMBL30219241 0.61 ALDH1A1 (0.65) ALDH1A1KDM4EGLAGAAJAK2
SCHEMBL1086528 0.61 ALDH1A1 (0.65) ALDH1A1KDM4EGLAGAAJAK2
SCHEMBL12505398 0.61 KDM4E (0.58) ALDH1A1KDM4EGLAGAAJAK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2142516-B1 PYRIMIDINE HYDRAZIDE COMPOUNDS AS PGDS INHIBITORS SANOFI SA (FR) 2012-12-26 — — EP claimed
US-8258130-B2 Pyrimidine hydrazide compounds as PGDS inhibitors SANOFI (FR) 2012-09-04 — — US claimed
US-20100048568-A1 PYRIMIDINE HYDRAZIDE COMPOUNDS AS PGDS INHIBITORS SANOFI-AVENTIS (FR) 2010-02-25 — — US claimed
EP-2142516-B1 PYRIMIDINE HYDRAZIDE COMPOUNDS AS PGDS INHIBITORS SANOFI SA (FR) 2012-12-26 — — EP disclosed
US-8258130-B2 Pyrimidine hydrazide compounds as PGDS inhibitors SANOFI (FR) 2012-09-04 — — US disclosed
US-20100048568-A1 PYRIMIDINE HYDRAZIDE COMPOUNDS AS PGDS INHIBITORS SANOFI-AVENTIS (FR) 2010-02-25 — — US disclosed
EP-2142516-A1 PYRIMIDINE HYDRAZIDE COMPOUNDS AS PGDS INHIBITORS Sanofi-Aventis (FR) 2010-01-13 — — EP disclosed
WO-2008121670-A1 PYRIMIDINE HYDRAZIDE COMPOUNDS AS PGDS INHIBITORS SANOFI-AVENTIS (FR) 2008-10-09 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100048568-A1 PYRIMIDINE HYDRAZIDE COMPOUNDS AS PGDS INHIBITORS HRH2, HRH1, HRH4 ALDH1A1 298/4885KDM4E 2494/4885GLA 1529/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.