Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 2/20 | 0.51 |
| ▸ | CD38 | P28907 | 6/20 | 0.39 |
| ▸ | BRD4 | O60885 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.36 |
| ▸ | CDK2 | P24941 | 3/20 | 0.36 |
| ▸ | GSK3A | P49840 | 2/20 | 0.36 |
| ▸ | GSK3B | P49841 | 2/20 | 0.36 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.36 |
| ▸ | MMP2 | P08253 | 1/20 | 0.35 |
| ▸ | MMP8 | P22894 | 1/20 | 0.35 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3229882 | 1.00 | EPHX2 (0.51) | EPHX2CD38BRD4POLBCYP2D6 | |
| SCHEMBL3539009 | 1.00 | EPHX2 (0.51) | EPHX2CD38BRD4POLBCYP2D6 | |
| SCHEMBL20488506 | 0.88 | EPHX2 (0.45) | EPHX2CD38BRD4POLBNPSR1 | |
| SCHEMBL20488504 | 0.88 | EPHX2 (0.45) | EPHX2CD38BRD4POLBNPSR1 | |
| SCHEMBL12409147 | 0.83 | EPHX2 (0.51) | EPHX2CD38CYP2D6CYP2B6CYP2C19 | |
| SCHEMBL12409405 | 0.83 | EPHX2 (0.51) | EPHX2CD38CYP2D6CYP2B6CYP2C19 | |
| SCHEMBL10082245 | 0.83 | EPHX2 (0.51) | EPHX2CD38CYP2D6CYP2B6CYP2C19 | |
| SCHEMBL4715595 | 0.82 | PDE7A (0.43) | EPHX2POLB | |
| Hydrochloric Acid SCHEMBL3546089 | 0.81 | EPHX2 (0.50) | EPHX2CD38BRD4CYP2D6CYP2B6 | |
| Hydrochloric Acid SCHEMBL2070160 | 0.81 | EPHX2 (0.50) | EPHX2CD38BRD4CYP2D6CYP2B6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022232320-A1 | SMALL MOLECULE INHIBITORS OF KRAS G12C MUTANT | MERCK SHARP & DOHME CORP. (US) | 2022-11-03 | — | — | WO | disclosed |
| US-20210198239-A1 | COMPOUNDS AND METHODS FOR CD73 MODULATION AND INDICATIONS THEREFOR | PLEXXIKON INC. | 2021-07-01 | — | — | US | disclosed |
| US-10618903-B2 | Heteroaryl substituted aminopyridine compounds | BRISTOL-MYERS SQUIBB COMPANY (US) | 2020-04-14 | — | — | US | disclosed |
| EP-3475270-B1 | HETEROARYL SUBSTITUTED AMINOPYRIDINE COMPOUNDS | BRISTOL MYERS SQUIBB CO (US) | 2020-02-26 | — | — | EP | disclosed |
| US-20190292191-A1 | HETEROARYL SUBSTITUTED AMINOPYRIDINE COMPOUNDS | BRISTOL MYERS SQUIBB CO (US) | 2019-09-26 | — | — | US | disclosed |
| CN-109796373-A | The carbamic synthetic method of cis-4- methoxycyclohexyl -1- | 南通江山农药化工股份有限公司 | 2019-05-24 | — | — | CN | disclosed |
| EP-3030560-B1 | BENZIMIDAZOLYL-METHYL UREA DERIVATIVES AS ALX RECEPTOR AGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2017-06-21 | — | — | EP | disclosed |
| US-9663473-B2 | Benzimidazolyl-methyl urea derivatives as ALX receptor agonists | ACTELION PHARMACEUTICALS LTD. (CH) | 2017-05-30 | — | — | US | disclosed |
| US-9580416-B2 | Inhibitors of Bruton's tyrosine kinase | PHARMACYCLICS LLC (US) | 2017-02-28 | — | — | US | disclosed |
| US-9556187-B2 | Substituted pyrrolo[3′,2′:5,6]pyrido[4,3-d]pyrimidines and JAK inhibitors comprising the same | NISSAN CHEMICAL INDUSTRIES, LTD. (JP) | 2017-01-31 | — | — | US | disclosed |
| EP-2742049-A1 | TRICYCLIC HETEROCYCLIC COMPOUNDS AND JAK INHIBITORS | Nissan Chemical Industries, Ltd. (JP) | 2014-06-18 | — | — | EP | disclosed |
| WO-2013024895-A1 | TRICYCLIC HETEROCYCLIC COMPOUNDS AND JAK INHIBITORS | NISSAN CHEMICAL INDUSTRIES, LTD. (JP) | 2013-02-21 | — | — | WO | disclosed |
| US-7803967-B2 | 4-alkoxy-cyclohexane-1-amino-carboxylic esters and processes for their preparation | BAYER CROPSCIENCE AG (DE) | 2010-09-28 | — | — | US | disclosed |
| WO-2010027097-A1 | TRI-SUBSTITUTED PYRIMIDINE COMPOUNDS AND THEIR USE AS PDE10 INHIBITORS | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2010-03-11 | — | — | WO | disclosed |
| US-20090227601-A1 | Bradykinin 1 Receptor Antagonists | AMGEN INC. (US) | 2009-09-10 | — | — | US | disclosed |
| US-20090156402-A1 | 4-ALKOXY-CYCLOHEXANE-1-AMINO-CARBOXYLIC ESTERS AND PROCESSES FOR THEIR PREPARATION | BAYER CROPSCIENCE AG (DE) | 2009-06-18 | — | — | US | disclosed |
| US-7511153-B2 | 4-alkoxy cyclohexane-1 amino carboxylic acid esters and method for the production thereof | BAYER CROPSCIENCE AG (DE) | 2009-03-31 | — | — | US | disclosed |
| US-20070043219-A1 | 4-Alkoxy cyclohexane-1 amino carboxylic acid esters and method for the production thereof | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2007-02-22 | — | — | US | disclosed |
| US-7148377-B2 | 4-Alkoxy cyclohexane-1-amino-carboxylic acid esters and method for the production thereof | BAYER CROPSCIENCE AG (DE) | 2006-12-12 | — | — | US | disclosed |
| US-20040039223-A1 | 4-Alkoxy cyclohexane-1 amino carboxylic acid esters and method for the production thereof | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2004-02-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210198239-A1 | COMPOUNDS AND METHODS FOR CD73 MODULATION AND INDICATIONS THEREFOR | ENTPD5, ADORA2A, ENTPD1 | EPHX2 959/4885CD38 14/4885BRD4 3271/4885 |
| US-20190292191-A1 | HETEROARYL SUBSTITUTED AMINOPYRIDINE COMPOUNDS | IRAK4, IRAK3, IRAK2 | EPHX2 2336/4885CD38 1161/4885BRD4 12/4885 |
| US-10618903-B2 | Heteroaryl substituted aminopyridine compounds | IRAK4, IRAK3, IRAK2 | EPHX2 2336/4885CD38 1161/4885BRD4 12/4885 |
| US-20070043219-A1 | 4-Alkoxy cyclohexane-1 amino carboxylic acid esters and method for the production thereof | ALDH7A1, DDC, ABAT | EPHX2 268/4885CD38 1909/4885BRD4 3956/4885 |
| US-20090156402-A1 | 4-ALKOXY-CYCLOHEXANE-1-AMINO-CARBOXYLIC ESTERS AND PROCESSES FOR THEIR PREPARATION | DDT, CYP4B1, ALDH7A1 | EPHX2 177/4885CD38 1780/4885BRD4 3560/4885 |
| US-20090227601-A1 | Bradykinin 1 Receptor Antagonists | BDKRB1, BDKRB2, VIPR1 | EPHX2 947/4885CD38 1036/4885BRD4 614/4885 |
| US-20040039223-A1 | 4-Alkoxy cyclohexane-1 amino carboxylic acid esters and method for the production thereof | ALDH7A1, CYP51A1, ABAT | EPHX2 354/4885CD38 1915/4885BRD4 3778/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.