Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES1 | P23141 | 4/20 | 0.50 |
| ▸ | FAAH | O00519 | 1/20 | 0.50 |
| ▸ | DAGLA | Q9Y4D2 | 1/20 | 0.44 |
| ▸ | QPCT | Q16769 | 1/20 | 0.41 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | HPGDS | O60760 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19501428 | 0.84 | ALDH1A1 (0.41) | ALDH1A1GAAMEN1NPC1MAPT | |
| SCHEMBL18876350 | 0.82 | MEN1 (0.41) | ALDH1A1GAAMEN1NPC1MAPT | |
| SCHEMBL2162896 | 0.81 | FAAH (0.47) | CES1FAAHDAGLA | |
| SCHEMBL2162742 | 0.80 | CES1 (0.67) | CES1FAAHDAGLAPLA2G4A | |
| SCHEMBL3229697 | 0.78 | CES1 (0.65) | CES1FAAHNPC1MAPTRAB9A | |
| SCHEMBL3223404 | 0.71 | CES1 (0.57) | CES1PLA2G4AMAPTSMN1; SMN2SIGMAR1 | |
| SCHEMBL27671494 | 0.71 | NPC1 (0.51) | ALDH1A1GAAMEN1NPC1MAPT | |
| SCHEMBL3225981 | 0.70 | NPC1 (0.53) | CES1FAAHDAGLAGAAMEN1 | |
| SCHEMBL9808857 | 0.69 | TAAR1 (0.55) | NPC1MAPTRAB9ASMN1; SMN2SIGMAR1 | |
| SCHEMBL27115453 | 0.69 | TAAR1 (0.55) | NPC1MAPTRAB9ASMN1; SMN2SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010005572-A2 | ALPHA-KETO HETEROCYCLES AS FAAH INHIBITORS | THE SCRIPPS RESEARCH INSTITUTE (US) | 2010-01-14 | — | — | WO | disclosed |