Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES1 | P23141 | 7/20 | 0.65 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.52 |
| ▸ | FAAH | O00519 | 5/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | FAAH2 | Q6GMR7 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2161883 | 0.80 | CES1 (0.65) | CES1FAAHFAAH2 | |
| SCHEMBL2161945 | 0.79 | CES1 (1.00) | CES1FAAHFAAH2 | |
| SCHEMBL3232148 | 0.78 | CES1 (0.50) | CES1FAAHKDM4ENPC1MAPT | |
| SCHEMBL8239921 | 0.75 | KDM4E (0.55) | CES1KDM4ENPC1GLAMAPT | |
| SCHEMBL13625437 | 0.73 | KDM4E (0.52) | CES1KDM4ENPC1GLAMAPT | |
| SCHEMBL14268968 | 0.70 | LOXL2 (0.59) | — | |
| SCHEMBL8890941 | 0.70 | RAB9A (0.51) | KDM4ENPC1MAPTRAB9A | |
| SCHEMBL13545505 | 0.69 | FAAH (0.64) | CES1FAAHFAAH2 | |
| SCHEMBL4873585 | 0.68 | LOXL2 (0.53) | KDM4ENPC1RAB9A | |
| SCHEMBL16203115 | 0.68 | FFAR1 (0.52) | CES1FAAHFAAH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010005572-A2 | ALPHA-KETO HETEROCYCLES AS FAAH INHIBITORS | THE SCRIPPS RESEARCH INSTITUTE (US) | 2010-01-14 | — | — | WO | claimed |
| WO-2010005572-A2 | ALPHA-KETO HETEROCYCLES AS FAAH INHIBITORS | THE SCRIPPS RESEARCH INSTITUTE (US) | 2010-01-14 | — | — | WO | disclosed |