Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.49 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.45 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | GHSR | Q92847 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2228231 | 0.83 | KMT2A (0.71) | KMT2ALTB4RLTB4R2TSHRMAPK1 | |
| SCHEMBL8693506 | 0.75 | LTB4R (0.64) | SIGMAR1LTB4RLTB4R2CYP1A2 | |
| SCHEMBL2228382 | 0.75 | KMT2A (0.63) | KMT2ACYP1A2TSHRMAPK1GAA | |
| SCHEMBL10269519 | 0.75 | KMT2A (0.63) | KMT2ATSHRMAPK1 | |
| SCHEMBL23832296 | 0.74 | HPGD (0.58) | KMT2ANPC1MAPK1 | |
| SCHEMBL8506886 | 0.74 | KMT2A (0.57) | KMT2ASIGMAR1LTB4RLTB4R2CYP1A2 | |
| SCHEMBL30498661 | 0.73 | KMT2A (0.57) | KMT2ALTB4RLTB4R2TSHRMAPK1 | |
| SCHEMBL14454157 | 0.73 | KMT2A (0.61) | KMT2ATSHRMAPK1 | |
| SCHEMBL15108850 | 0.73 | KMT2A (0.61) | KMT2ATSHRMAPK1 | |
| SCHEMBL6246604 | 0.72 | SIGMAR1 (0.68) | SIGMAR1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010022355-A1 | COMPOUNDS AND METHODS FOR TREATING RESPIRATORY DISEASES | PURDUE RESEARCH FOUNDATION (US) | 2010-02-25 | — | — | WO | disclosed |