Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 6/20 | 0.48 |
| ▸ | MAPT | P10636 | 5/20 | 0.48 |
| ▸ | NPC1 | O15118 | 5/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 6/20 | 0.46 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.43 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.43 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.43 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3234299 | 0.80 | RAB9A (0.48) | RAB9AMAPTNPC1ALDH1A1LMNA | |
| SCHEMBL3233744 | 0.80 | KMT2A (0.47) | RAB9AMAPTNPC1ALDH1A1LMNA | |
| SCHEMBL3262923 | 0.75 | GRM1 (0.44) | MAPTALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL7367407 | 0.74 | MEN1 (0.57) | RAB9AMAPTNPC1ALDH1A1LMNA | |
| SCHEMBL3232242 | 0.73 | HDAC1 (0.65) | RAB9AMAPTNPC1ALDH1A1LMNA | |
| SCHEMBL3240737 | 0.70 | MAPK14 (0.48) | RAB9AMAPTNPC1ALDH1A1LMNA | |
| SCHEMBL3235671 | 0.69 | GRM1 (0.44) | RAB9AMAPTNPC1MEN1KMT2A | |
| SCHEMBL3234453 | 0.67 | HDAC3 (0.69) | RAB9AMAPTNPC1ALDH1A1LMNA | |
| SCHEMBL3265770 | 0.67 | HDAC1 (0.38) | LMNAHDAC3HDAC1 | |
| SCHEMBL2827565 | 0.66 | RAB9A (0.61) | RAB9AMAPTNPC1ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010028193-A1 | COMPOUNDS INCLUDING PIMELIC ACID DERIVATIVES AS HDAC INHIBITORS | REPLIGEN CORPORATION (US) | 2010-03-11 | — | — | WO | disclosed |