Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM1 | Q13255 | 7/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.41 |
| ▸ | MEF2D | Q14814 | 2/20 | 0.41 |
| ▸ | EP300 | Q09472 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.39 |
| ▸ | PRKACA | P17612 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.39 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.39 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3235671 | 0.86 | GRM1 (0.44) | GRM1MEN1MAPTKMT2ASMN1; SMN2 | |
| SCHEMBL3240737 | 0.80 | MAPK14 (0.48) | GRM1MEN1ALDH1A1LMNAGAA | |
| SCHEMBL1064934 | 0.76 | HDAC3 (0.42) | LMNAGAAMAPTHDAC4HDAC1 | |
| SCHEMBL3234078 | 0.76 | HPGD (0.43) | MEN1ALDH1A1LMNAGAAMAPT | |
| SCHEMBL3238500 | 0.75 | RAB9A (0.48) | GRM1MEN1ALDH1A1LMNAMAPT | |
| SCHEMBL3233744 | 0.75 | KMT2A (0.47) | MEN1ALDH1A1LMNAMAPTKMT2A | |
| SCHEMBL3234299 | 0.73 | RAB9A (0.48) | MEN1ALDH1A1LMNAMAPTKMT2A | |
| SCHEMBL3233951 | 0.72 | HDAC3 (0.42) | SMN1; SMN2HDAC4HDAC1HDAC2HDAC3 | |
| SCHEMBL3242812 | 0.72 | ALDH1A1 (0.40) | MEN1ALDH1A1LMNAMAPTKMT2A | |
| SCHEMBL16369620 | 0.72 | ALDH1A1 (0.40) | MEN1ALDH1A1LMNAMAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010028193-A1 | COMPOUNDS INCLUDING PIMELIC ACID DERIVATIVES AS HDAC INHIBITORS | REPLIGEN CORPORATION (US) | 2010-03-11 | — | — | WO | disclosed |