Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 4/20 | 0.40 |
| ▸ | KDR | P35968 | 9/20 | 0.39 |
| ▸ | FLT1 | P17948 | 7/20 | 0.39 |
| ▸ | TEK | Q02763 | 6/20 | 0.39 |
| ▸ | SRC | P12931 | 2/20 | 0.38 |
| ▸ | PDGFRB | P09619 | 5/20 | 0.37 |
| ▸ | CSF1R | P07333 | 3/20 | 0.37 |
| ▸ | KIT | P10721 | 3/20 | 0.37 |
| ▸ | FLT4 | P35916 | 3/20 | 0.37 |
| ▸ | FLT3 | P36888 | 3/20 | 0.37 |
| ▸ | AURKA | O14965 | 2/20 | 0.37 |
| ▸ | LCK | P06239 | 2/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.37 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.37 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.37 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.37 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.37 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.37 |
| ▸ | RIPK1 | Q13546 | 3/20 | 0.37 |
| ▸ | GSK3A | P49840 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3837284 | 0.90 | RET (0.44) | RETKDRFLT1TEKSRC | |
| SCHEMBL3235234 | 0.90 | SRC (0.38) | RETKDRSRCFLT3RIPK1 | |
| SCHEMBL3239039 | 0.89 | RET (0.40) | RETKDRFLT1TEKSRC | |
| SCHEMBL3834618 | 0.85 | KDR (0.43) | RETKDRFLT1SRCCSF1R | |
| SCHEMBL3235223 | 0.83 | KCNH2 (0.41) | RETKDRFLT1TEKSRC | |
| SCHEMBL3241780 | 0.82 | EPHX2 (0.49) | RETKDRPDGFRBCSF1RKIT | |
| SCHEMBL13790976 | 0.82 | KDM4E (0.42) | KDRAURKAAURKBNTRK1RAF1 | |
| SCHEMBL3238527 | 0.81 | RET (0.46) | RETKDRFLT1TEKSRC | |
| SCHEMBL3829680 | 0.79 | RET (0.50) | RETKDRFLT1TEKSRC | |
| SCHEMBL3837288 | 0.78 | ALDH1A1 (0.45) | RETKDRFLT1TEKSRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1809630-B1 | 4-AMINO-5-OXO-8-PHENYL-5H-PYRIDO-[2,3-D]-PYRIMIDINE DERIVATIVES AS TYROSINE KINASE AND RAF KINASE INHIBITORS FOR THE TREATMENT OF TUMOURS | MERCK PATENT GMBH (DE) | 2009-04-15 | — | — | EP | claimed |
| US-20080146560-A1 | 4-Amino-5-Oxo-8-Phenyl-5H-Pyrido(2,3-D) Pyrimidine Derivatives as Tyrosine Kinase and Raf Kinase Inhibitors for the Treatment of Tumours | MERCK PATENT GMBH (DE) | 2008-06-19 | — | — | US | claimed |
| US-7745434-B2 | 4-Amino-5-oxo-8-phenyl-5H-pyrido(2,3-D) pyrimidine derivatives as tyrosine kinase and raf kinase inhibitors for the treatment of tumours | MERCK PATENT GMBH (DE) | 2010-06-29 | — | — | US | disclosed |
| US-7745434-B2 | 4-Amino-5-oxo-8-phenyl-5H-pyrido(2,3-D) pyrimidine derivatives as tyrosine kinase and raf kinase inhibitors for the treatment of tumours | MERCK PATENT GMBH (DE) | 2010-06-29 | — | — | US | disclosed |
| US-7745434-B2 | 4-Amino-5-oxo-8-phenyl-5H-pyrido(2,3-D) pyrimidine derivatives as tyrosine kinase and raf kinase inhibitors for the treatment of tumours | MERCK PATENT GMBH (DE) | 2010-06-29 | — | — | US | disclosed |
| EP-1809630-B1 | 4-AMINO-5-OXO-8-PHENYL-5H-PYRIDO-[2,3-D]-PYRIMIDINE DERIVATIVES AS TYROSINE KINASE AND RAF KINASE INHIBITORS FOR THE TREATMENT OF TUMOURS | MERCK PATENT GMBH (DE) | 2009-04-15 | — | — | EP | disclosed |
| US-20080146560-A1 | 4-Amino-5-Oxo-8-Phenyl-5H-Pyrido(2,3-D) Pyrimidine Derivatives as Tyrosine Kinase and Raf Kinase Inhibitors for the Treatment of Tumours | MERCK PATENT GMBH (DE) | 2008-06-19 | — | — | US | disclosed |
| US-20080146560-A1 | 4-Amino-5-Oxo-8-Phenyl-5H-Pyrido(2,3-D) Pyrimidine Derivatives as Tyrosine Kinase and Raf Kinase Inhibitors for the Treatment of Tumours | MERCK PATENT GMBH (DE) | 2008-06-19 | — | — | US | disclosed |
| US-20080146560-A1 | 4-Amino-5-Oxo-8-Phenyl-5H-Pyrido(2,3-D) Pyrimidine Derivatives as Tyrosine Kinase and Raf Kinase Inhibitors for the Treatment of Tumours | MERCK PATENT GMBH (DE) | 2008-06-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080146560-A1 | 4-Amino-5-Oxo-8-Phenyl-5H-Pyrido(2,3-D) Pyrimidine Derivatives as Tyrosine Kinase and Raf Kinase Inhibitors for the Treatment of Tumours | TIE1, PDXK, ERBB2 | RET 5/4885KDR 8/4885FLT1 7/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.