Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 19/20 | 0.41 |
| ▸ | GRIN1 | Q05586 | 6/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3247390 | 0.89 | GRIN2B (0.39) | GRIN2BGRIN1KDM4EALDH1A1LMNA | |
| SCHEMBL3239092 | 0.85 | GRIN2B (0.43) | GRIN2BGRIN1 | |
| SCHEMBL3128413 | 0.85 | KDM4E (0.36) | KDM4EALDH1A1LMNA | |
| SCHEMBL3124617 | 0.83 | GRIN2B (0.42) | GRIN2B | |
| SCHEMBL3244879 | 0.81 | LMNA (0.38) | KDM4EALDH1A1LMNA | |
| SCHEMBL13521688 | 0.80 | GRIN2B (0.41) | GRIN2B | |
| SCHEMBL3242106 | 0.80 | GRIN2B (0.45) | GRIN2BGRIN1 | |
| SCHEMBL3240957 | 0.79 | GRIN2B (0.41) | GRIN2BGRIN1 | |
| SCHEMBL3246489 | 0.77 | CYP11B2 (0.36) | GRIN2BKDM4EALDH1A1LMNA | |
| SCHEMBL3247029 | 0.76 | GRIN2B (0.43) | GRIN2BGRIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010008777-A2 | FUSED AZABICYCLIC PYRIDINES | LIGAND PHARMACEUTICALS INC. (US) | 2010-01-21 | — | — | WO | claimed |
| WO-2010008777-A2 | FUSED AZABICYCLIC PYRIDINES | LIGAND PHARMACEUTICALS INC. (US) | 2010-01-21 | — | — | WO | disclosed |