Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METTL3 | Q86U44 | 1/20 | 0.47 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 3/20 | 0.31 |
| ▸ | THRB | P10828 | 2/20 | 0.31 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.31 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.31 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.31 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.31 |
| ▸ | EGFR | P00533 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3243314 | 0.93 | METTL3 (0.53) | METTL3NPC1TP53PLA2G4AEGFR | |
| SCHEMBL3235235 | 0.92 | METTL3 (0.53) | METTL3MRGPRX4TP53THRBRXFP1 | |
| SCHEMBL3241758 | 0.91 | METTL3 (0.43) | METTL3MRGPRX4TP53THRBRXFP1 | |
| SCHEMBL3239885 | 0.91 | METTL3 (0.48) | METTL3MRGPRX4PLA2G4A | |
| SCHEMBL1043002 | 0.91 | METTL3 (0.57) | METTL3MRGPRX4MEN1NPC1KMT2A | |
| SCHEMBL1043000 | 0.91 | METTL3 (0.57) | METTL3MRGPRX4MEN1NPC1KMT2A | |
| SCHEMBL3234887 | 0.90 | METTL3 (0.44) | METTL3MRGPRX4MEN1NPC1KMT2A | |
| SCHEMBL3245711 | 0.90 | METTL3 (0.42) | METTL3MRGPRX4TP53RXFP1ALDH1A1 | |
| SCHEMBL3241571 | 0.87 | METTL3 (0.47) | METTL3PLA2G4AEGFR | |
| SCHEMBL3245374 | 0.86 | METTL3 (0.41) | METTL3MEN1KMT2ATHRBRXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1564210-B9 | 4-OXOQUINOLINE COMPOUNDS AND UTILIZATION THEREOF AS HIV INTEGRASE INHIBITORS | JAPAN TOBACCO INC (JP) | 2010-03-31 | — | — | EP | claimed |
| EP-1564210-B1 | 4-OXOQUINOLINE COMPOUNDS AND UTILIZATION THEREOF AS HIV INTEGRASE INHIBITORS | JAPAN TOBACCO INC (JP) | 2009-09-16 | — | — | EP | claimed |