Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX3 | P56373 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | PRNP | P04156 | 1/20 | 0.39 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.39 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | MDM4 | O15151 | 1/20 | 0.39 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3234629 | 0.91 | TP53 (0.50) | P2RX3MEN1KMT2ATP53SMN1; SMN2 | |
| SCHEMBL3234265 | 0.86 | EGLN2 (0.46) | P2RX3MEN1KMT2ASMN1; SMN2RXFP1 | |
| SCHEMBL3238407 | 0.85 | LMNA (0.55) | MEN1KMT2ATP53 | |
| SCHEMBL3241020 | 0.85 | SLC22A12 (0.45) | P2RX3SMN1; SMN2RXFP1MAPTMAPK8 | |
| SCHEMBL3243021 | 0.84 | SERPINE1 (0.49) | P2RX3MEN1KMT2ATP53SMN1; SMN2 | |
| SCHEMBL3238079 | 0.83 | ICMT (0.45) | TP53SMN1; SMN2RXFP1MAPTMAPK8 | |
| SCHEMBL3233866 | 0.81 | AKR1B1 (0.53) | MEN1KMT2ATP53MAPTMAPK8 | |
| SCHEMBL9416441 | 0.80 | MAPK8 (0.43) | P2RX3MAPK8POLBCNR2 | |
| SCHEMBL3237157 | 0.79 | MAPT (0.48) | MEN1KMT2ATP53SMN1; SMN2RXFP1 | |
| SCHEMBL3234589 | 0.79 | CHRM1 (0.55) | TP53SMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1963271-B1 | QUINOLONE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | MERCK SHARP & DOHME (US) | 2010-07-28 | — | — | EP | claimed |