Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.41 |
| ▸ | PYCR1 | P32322 | 4/20 | 0.39 |
| ▸ | ACHE | P22303 | 2/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.34 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.34 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | LSS | P48449 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3240150 | 0.81 | PYCR1 (0.56) | ALDH1A1KDM4ESMN1; SMN2RIPK1PYCR1 | |
| SCHEMBL23374698 | 0.79 | RIPK1 (0.47) | HTTALDH1A1KDM4ESMN1; SMN2RIPK1 | |
| SCHEMBL23972532 | 0.77 | HRH3 (0.50) | HTTALDH1A1RIPK1TSHRHTR2A | |
| SCHEMBL23374701 | 0.75 | RIPK1 (0.41) | HTTALDH1A1KDM4ESMN1; SMN2RIPK1 | |
| SCHEMBL3242409 | 0.75 | ALDH1A1 (0.54) | ALDH1A1KDM4ESMN1; SMN2PYCR1ACHE | |
| SCHEMBL25488451 | 0.70 | RIPK1 (0.50) | HTTALDH1A1KDM4ERIPK1MAOA | |
| SCHEMBL27258858 | 0.70 | HTT (0.46) | HTTALDH1A1RIPK1MAOAMAOB | |
| SCHEMBL3191532 | 0.69 | PYCR1 (0.67) | ALDH1A1KDM4ESMN1; SMN2RIPK1PYCR1 | |
| SCHEMBL3771308 | 0.69 | HRH3 (0.64) | ALDH1A1PYCR1TSHR | |
| SCHEMBL30093198 | 0.69 | PYCR1 (0.67) | ALDH1A1KDM4ESMN1; SMN2RIPK1PYCR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100144733-A1 | Compounds, compositions and methods comprising heteroaromatic derivatives | INSTITUTE FOR ONEWORLD HEALTH | 2010-06-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100144733-A1 | Compounds, compositions and methods comprising heteroaromatic derivatives | CFTR, PKD1, PKD2 | HTT 738/4885ALDH1A1 2115/4885KDM4E 4565/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.