Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CBFB | Q13951 | 4/20 | 0.34 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.33 |
| ▸ | CDK1 | P06493 | 1/20 | 0.33 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.33 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.33 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.33 |
| ▸ | METAP1 | P53582 | 2/20 | 0.33 |
| ▸ | METAP2 | P50579 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | CCR1 | P32246 | 1/20 | 0.32 |
| ▸ | CCR5 | P51681 | 1/20 | 0.32 |
| ▸ | CCR8 | P51685 | 1/20 | 0.32 |
| ▸ | BLM | P54132 | 1/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
| ▸ | DOHH | Q9BU89 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1640279 | 0.94 | CBFB (0.34) | CBFBCCNB2CDK1CCNB1GSK3B | |
| SCHEMBL6761273 | 0.88 | KDM4E (0.41) | CBFBCCNB2CDK1CCNB1GSK3B | |
| SCHEMBL1641273 | 0.85 | CCNB2 (0.39) | CBFBCCNB2CDK1CCNB1GSK3B | |
| SCHEMBL1640968 | 0.85 | — | — | |
| SCHEMBL1641262 | 0.77 | HSD17B10 (0.31) | — | |
| SCHEMBL599823 | 0.74 | KDM4E (0.52) | CCNB2CDK1CCNB1GSK3BCDK5 | |
| SCHEMBL3246557 | 0.74 | — | — | |
| SCHEMBL241718 | 0.69 | — | — | |
| SCHEMBL16924935 | 0.69 | RAB9A (0.32) | CCNB2CDK1CCNB1GSK3BCDK5 | |
| SCHEMBL4407509 | 0.68 | KDM4E (0.43) | METAP1KDM4ELMNACYP1A2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1469001-B1 | Corroles, including chiral derivatives and the use thereof | TECHNION RES & DEV FOUNDATION (IL) | 2010-05-05 | — | — | EP | disclosed |
| EP-1117666-B1 | PROCESS FOR THE PREPARATION OF CORROLES AND SEVERAL SUCH NEW COMPOUNDS, INCLUDING CHIRAL DERIVATIVES, AND THE USE THEREOF | TECHNION RES & DEV FOUNDATION (IL) | 2004-12-01 | — | — | EP | disclosed |
| EP-1469001-A1 | Corroles, including chiral derivatives and the use thereof | Technion Research & Development Foundation Limited (IL) | 2004-10-20 | — | — | EP | disclosed |
| US-6730666-B1 | INHIBITION OF GROWTH FACTOR TYROSINE KINASE RECEPTOR ACTIVITY, PARTICULARLY INHIBITION OF ANGIOGENESIS AND RELATED DISORDERS, TUMOR PROGRESSION AND GROWTH FACTOR RELATED SKELETAL DISORDERS, BY PORPHYRIN AND CORROLE COMPOUNDS | YEDA RESEARCH AND DEVELOPMENT CO. LTD. (IL) | 2004-05-04 | — | — | US | disclosed |
| US-6541628-B1 | Solvent-free condensation of an aldehyde with a pyrrole derivative to form corroles, salts or complexes | TECHNION RESEARCH AND DEVELOPMENT FOUNDATION LTD. (IL) | 2003-04-01 | — | — | US | disclosed |
| EP-1117666-A2 | PROCESS FOR THE PREPARATION OF CORROLES AND SEVERAL SUCH NEW COMPOUNDS, INCLUDING CHIRAL DERIVATIVES, AND THE USE THEREOF | Technion Research & Development Foundation Limited (IL) | 2001-07-25 | — | — | EP | disclosed |
| WO-2000027379-A2 | PHARMACEUTICAL COMPOSITIONS COMPRISING PORPHYRINS AND SOME NOVEL PORPHYRIN DERIVATIVES | YEDA RESEARCH AND DEVELOPMENT CO. LTD. (IL) | 2000-05-18 | — | — | WO | disclosed |
| WO-2000018771-A2 | PROCESS FOR THE PREPARATION OF CORROLES AND SEVERAL SUCH NEW COMPOUNDS, INCLUDING CHIRAL DERIVATIVES, AND THE USE THEREOF | TECHNION RESEARCH AND DEVELOPMENT FOUNDATION LTD. (IL) | 2000-04-06 | — | — | WO | disclosed |