Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNB2 | O95067 | 1/20 | 0.39 |
| ▸ | CDK1 | P06493 | 1/20 | 0.39 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.39 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.39 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.38 |
| ▸ | METAP1 | P53582 | 6/20 | 0.38 |
| ▸ | LMNA | P02545 | 5/20 | 0.38 |
| ▸ | CCR1 | P32246 | 2/20 | 0.38 |
| ▸ | CCR5 | P51681 | 2/20 | 0.38 |
| ▸ | CCR8 | P51685 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | DOHH | Q9BU89 | 1/20 | 0.38 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.38 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1640279 | 0.90 | CBFB (0.34) | CCNB2CDK1CCNB1GSK3BCDK5 | |
| SCHEMBL3241102 | 0.85 | CBFB (0.34) | CCNB2CDK1CCNB1GSK3BCDK5 | |
| SCHEMBL599823 | 0.85 | KDM4E (0.52) | CCNB2CDK1CCNB1GSK3BCDK5 | |
| SCHEMBL4407509 | 0.78 | KDM4E (0.43) | KDM4EMETAP1LMNACCR1CCR5 | |
| SCHEMBL4409178 | 0.78 | KDM4E (0.43) | KDM4EMETAP1LMNACCR1CCR5 | |
| SCHEMBL4413920 | 0.78 | KDM4E (0.43) | KDM4EMETAP1LMNACCR1CCR5 | |
| SCHEMBL4410148 | 0.78 | KDM4E (0.43) | KDM4EMETAP1LMNACCR1CCR5 | |
| SCHEMBL16924935 | 0.76 | RAB9A (0.32) | CCNB2CDK1CCNB1GSK3BCDK5 | |
| SCHEMBL20550833 | 0.74 | KDM4E (0.43) | KDM4EMETAP1LMNACCR1CCR5 | |
| SCHEMBL18795855 | 0.74 | KDM4E (0.43) | KDM4EMETAP1LMNACCR1CCR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140045809-A1 | CORROLES FOR NEUROPROTECTION AND NEURORESCUE | TECHNION RESEARCH AND DEVELOPMENT FOUNDATION LTD. (IL) | 2014-02-13 | — | — | US | disclosed |
| EP-2244701-B1 | CORROLES FOR NEUROPROTECTION AND NEURORESCUE | TECHNION RES & DEV FOUNDATION (IL) | 2012-05-09 | — | — | EP | disclosed |
| US-20110098262-A1 | CORROLES FOR NEUROPROTECTION AND NEURORESCUE | TECHNION RESEARCH AND DEVELOPEMENT FOUNDATION, LTD. (IL) | 2011-04-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110098262-A1 | CORROLES FOR NEUROPROTECTION AND NEURORESCUE | IAPP, CASP3, SOD1 | CCNB2 4746/4885CDK1 4728/4885CCNB1 4714/4885 |
| US-20140045809-A1 | CORROLES FOR NEUROPROTECTION AND NEURORESCUE | IAPP, CASP3, SOD1 | CCNB2 4746/4885CDK1 4728/4885CCNB1 4714/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.