SCHEMBL1641262

SCHEMBL1641262

COc1c(F)c(F)c(C2=C3C=CC(=N3)C(c3c(F)c(F)c(OC)c(F)c3F)=C3C=CC(=N3)c3ccc([nH]3)C(c3c(F)c(F)c(OC)c(F)c3F)=C3C=CC2=N3)c(F)c1F

nearest known ligand 0.31

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
▸ HSD17B10 Q99714 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1640968 0.87 — —
SCHEMBL3241102 0.77 CBFB (0.34) —
SCHEMBL3243506 0.76 — —
SCHEMBL1639456 0.74 — —
SCHEMBL1640279 0.73 CBFB (0.34) —
SCHEMBL17651806 0.72 — —
SCHEMBL241718 0.71 — —
SCHEMBL3270945 0.70 — —
SCHEMBL23628544 0.69 — —
SCHEMBL1438735 0.69 — —

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2192899-B1 TRANSITION METAL COMPLEXES OF CORROLES FOR PREVENTING CARDIOVASCULAR DISEASES OR DISORDERS TECHNION RES & DEV FOUNDATION (IL) 2014-10-01 — — EP disclosed
US-8791099-B2 Transition metal complexes of corroles for preventing cardiovascular diseases or disorders TECHNION RESEARCH AND DEVELOPMENT FOUNDATION LTD. (IL) 2014-07-29 — — US disclosed
US-20140045809-A1 CORROLES FOR NEUROPROTECTION AND NEURORESCUE TECHNION RESEARCH AND DEVELOPMENT FOUNDATION LTD. (IL) 2014-02-13 — — US disclosed
EP-2244701-B1 CORROLES FOR NEUROPROTECTION AND NEURORESCUE TECHNION RES & DEV FOUNDATION (IL) 2012-05-09 — — EP disclosed
US-20110144078-A1 TRANSITION METAL COMPLEXES OF CORROLES FOR PREVENTING CARDIOVASCULAR DISEASES OR DISORDERS TECHNION RESEARCH AND DEVELOPMENT FOUNDATION LTD. (IL) 2011-06-16 — — US disclosed
US-20110098262-A1 CORROLES FOR NEUROPROTECTION AND NEURORESCUE TECHNION RESEARCH AND DEVELOPEMENT FOUNDATION, LTD. (IL) 2011-04-28 — — US disclosed
EP-2244701-A2 CORROLES FOR NEUROPROTECTION AND NEURORESCUE Technion Research and Development Foundation, Ltd. (IL) 2010-11-03 — — EP disclosed
EP-2192899-A1 TRANSITION METAL COMPLEXES OF CORROLES FOR PREVENTING CARDIOVASCULAR DISEASES OR DISORDERS Technion Research and Development Foundation, Ltd. (IL) 2010-06-09 — — EP disclosed
WO-2009095923-A2 CORROLES FOR NEUROPROTECTION AND NEURORESCUE TECHNION RESEARCH AND DEVELOPMENT FOUNDATION LTD (IL) 2009-08-06 — — WO disclosed
WO-2009027965-A1 TRANSITION METAL COMPLEXES OF CORROLES FOR PREVENTING CARDIOVASCULAR DISEASES OR DISORDERS TECHNION RESEARCH AND DEVELOPMENT FOUNDATION LTD. (IL) 2009-03-05 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110098262-A1 CORROLES FOR NEUROPROTECTION AND NEURORESCUE IAPP, CASP3, SOD1 HSD17B10 2689/4885
US-20140045809-A1 CORROLES FOR NEUROPROTECTION AND NEURORESCUE IAPP, CASP3, SOD1 HSD17B10 2689/4885
US-20110144078-A1 TRANSITION METAL COMPLEXES OF CORROLES FOR PREVENTING CARDIOVASCULAR DISEASES OR DISORDERS FABP3, SLC39A14, SLC39A3 HSD17B10 915/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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