Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CBFB | Q13951 | 4/20 | 0.34 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.33 |
| ▸ | CDK1 | P06493 | 1/20 | 0.33 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.33 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.33 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.33 |
| ▸ | METAP1 | P53582 | 2/20 | 0.32 |
| ▸ | METAP2 | P50579 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | CCR1 | P32246 | 1/20 | 0.31 |
| ▸ | CCR5 | P51681 | 1/20 | 0.31 |
| ▸ | CCR8 | P51685 | 1/20 | 0.31 |
| ▸ | BLM | P54132 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3241102 | 0.94 | CBFB (0.34) | CBFBCCNB2CDK1CCNB1GSK3B | |
| SCHEMBL1641273 | 0.90 | CCNB2 (0.39) | CBFBCCNB2CDK1CCNB1GSK3B | |
| SCHEMBL1640968 | 0.84 | — | — | |
| SCHEMBL6761273 | 0.84 | KDM4E (0.41) | CBFBCCNB2CDK1CCNB1GSK3B | |
| SCHEMBL599823 | 0.77 | KDM4E (0.52) | CCNB2CDK1CCNB1GSK3BCDK5 | |
| SCHEMBL3246557 | 0.75 | — | — | |
| SCHEMBL1641262 | 0.73 | HSD17B10 (0.31) | — | |
| SCHEMBL241718 | 0.72 | — | — | |
| SCHEMBL23628544 | 0.70 | — | — | |
| SCHEMBL1438735 | 0.70 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140045809-A1 | CORROLES FOR NEUROPROTECTION AND NEURORESCUE | TECHNION RESEARCH AND DEVELOPMENT FOUNDATION LTD. (IL) | 2014-02-13 | — | — | US | disclosed |
| EP-2244701-B1 | CORROLES FOR NEUROPROTECTION AND NEURORESCUE | TECHNION RES & DEV FOUNDATION (IL) | 2012-05-09 | — | — | EP | disclosed |
| US-20110098262-A1 | CORROLES FOR NEUROPROTECTION AND NEURORESCUE | TECHNION RESEARCH AND DEVELOPEMENT FOUNDATION, LTD. (IL) | 2011-04-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110098262-A1 | CORROLES FOR NEUROPROTECTION AND NEURORESCUE | IAPP, CASP3, SOD1 | CBFB 1081/4885CCNB2 4746/4885CDK1 4728/4885 |
| US-20140045809-A1 | CORROLES FOR NEUROPROTECTION AND NEURORESCUE | IAPP, CASP3, SOD1 | CBFB 1081/4885CCNB2 4746/4885CDK1 4728/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.