Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FASN | P49327 | 2/20 | 0.43 |
| ▸ | PRKAB2 | O43741 | 5/20 | 0.35 |
| ▸ | PRKAG1 | P54619 | 5/20 | 0.35 |
| ▸ | PRKAA2 | P54646 | 5/20 | 0.35 |
| ▸ | PRKAA1 | Q13131 | 5/20 | 0.35 |
| ▸ | PRKAG3 | Q9UGI9 | 5/20 | 0.35 |
| ▸ | PRKAG2 | Q9UGJ0 | 5/20 | 0.35 |
| ▸ | PRKAB1 | Q9Y478 | 5/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | TYMS | P04818 | 1/20 | 0.33 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.33 |
| ▸ | CSF1R | P07333 | 1/20 | 0.33 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3250925 | 0.87 | NR1H2 (0.38) | FASNMEN1MAPTKMT2ASMN1; SMN2 | |
| SCHEMBL3252420 | 0.87 | FASN (0.44) | FASNPRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL3249044 | 0.81 | PRKAG1 (0.48) | FASNPRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL3250736 | 0.81 | CAMKK2 (0.36) | FASNMAPTBRD4NR1H2JAK1 | |
| SCHEMBL3252385 | 0.79 | WEE1 (0.36) | MEN1POLBMAPTKMT2ASMN1; SMN2 | |
| SCHEMBL3243041 | 0.79 | WEE1 (0.38) | MEN1POLBMAPTKMT2ACSF1R | |
| SCHEMBL4159323 | 0.79 | FASN (0.45) | FASNPRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL3254886 | 0.78 | PAK1 (0.42) | MEN1POLBMAPTKMT2ASMN1; SMN2 | |
| SCHEMBL3250589 | 0.78 | NR1H2 (0.36) | FASNMAP3K5BRD4NR1H2JAK1 | |
| SCHEMBL3255432 | 0.77 | MET (0.41) | MEN1POLBMAPTKMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899335-B1 | PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | PF MEDICAMENT (FR) | 2010-05-19 | — | — | EP | claimed |