Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WEE1 | P30291 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 6/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.30 |
| ▸ | TP53 | P04637 | 2/20 | 0.30 |
| ▸ | TYMS | P04818 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
| ▸ | JAK2 | O60674 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3243041 | 0.89 | WEE1 (0.38) | WEE1BRD4KDM4EMAPTMEN1 | |
| SCHEMBL3251688 | 0.86 | JAK3 (0.39) | WEE1KDM4EMAPTJAK2NPC1 | |
| SCHEMBL3250925 | 0.86 | NR1H2 (0.38) | WEE1KDM4EMAPTMEN1KMT2A | |
| SCHEMBL3244660 | 0.86 | TYMS (0.37) | WEE1KDM4EMAPTMEN1KMT2A | |
| SCHEMBL3250557 | 0.82 | MAPT (0.41) | KDM4EMAPTMEN1KMT2AHSD17B10 | |
| SCHEMBL3253850 | 0.82 | SCN9A (0.38) | WEE1KDM4EMAPTMEN1KMT2A | |
| SCHEMBL3241840 | 0.81 | KDM4E (0.41) | KDM4EMAPTMEN1KMT2AHSD17B10 | |
| SCHEMBL3241482 | 0.81 | WEE1 (0.39) | WEE1BRD4MAPTHSD17B10LMNA | |
| SCHEMBL3249063 | 0.80 | CDK2 (0.39) | BRD4KDM4EHSD17B10LMNATYMS | |
| SCHEMBL3255332 | 0.80 | ADORA3 (0.40) | WEE1KDM4EMAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899335-B1 | PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | PF MEDICAMENT (FR) | 2010-05-19 | — | — | EP | claimed |