SCHEMBL3241874

SCHEMBL3241874

CC(C)Oc1cc(Cc2cccc(Cl)c2F)cc2c(=O)c(OC(=O)O)cn([C@H](CO)C(C)(C)C)c12

nearest known ligand 0.45

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
METTL3 Q86U44 1/20 0.45
HIF1A Q16665 1/20 0.31
SLC16A3 O15427 1/20 0.30
SLC16A1 P53985 1/20 0.30
MCTS1 Q9ULC4 1/20 0.30
CFD P00746 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3235872 0.92 METTL3 (0.50) METTL3HIF1ACFD
SCHEMBL1046034 0.92 METTL3 (0.55) METTL3HIF1ASLC16A3SLC16A1MCTS1
SCHEMBL1046033 0.92 METTL3 (0.55) METTL3HIF1ASLC16A3SLC16A1MCTS1
SCHEMBL3234887 0.91 METTL3 (0.44) METTL3
SCHEMBL3237655 0.91 METTL3 (0.54) METTL3HIF1ACFD
SCHEMBL3239885 0.91 METTL3 (0.48) METTL3HIF1ACFD
SCHEMBL3242298 0.88 METTL3 (0.44) METTL3HIF1ACFD
SCHEMBL3243702 0.87 METTL3 (0.43) METTL3
SCHEMBL3240115 0.85 METTL3 (0.59) METTL3HIF1ACFD
SCHEMBL3242029 0.85 METTL3 (0.43) METTL3CFD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1564210-B9 4-OXOQUINOLINE COMPOUNDS AND UTILIZATION THEREOF AS HIV INTEGRASE INHIBITORS JAPAN TOBACCO INC (JP) 2010-03-31 EP claimed
EP-1564210-B1 4-OXOQUINOLINE COMPOUNDS AND UTILIZATION THEREOF AS HIV INTEGRASE INHIBITORS JAPAN TOBACCO INC (JP) 2009-09-16 EP claimed