Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 4/20 | 0.54 |
| ▸ | TEK | Q02763 | 1/20 | 0.51 |
| ▸ | FYN | P06241 | 1/20 | 0.49 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.49 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.49 |
| ▸ | CTSC | P53634 | 2/20 | 0.49 |
| ▸ | SYK | P43405 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | CDK8 | P49336 | 1/20 | 0.46 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.45 |
| ▸ | EGFR | P00533 | 1/20 | 0.45 |
| ▸ | ITK | Q08881 | 1/20 | 0.45 |
| ▸ | KDR | P35968 | 1/20 | 0.45 |
| ▸ | ABL1 | P00519 | 2/20 | 0.45 |
| ▸ | BCR | P11274 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | CRHBP | P24387 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3247802 | 0.93 | BRAF (0.58) | BRAFFYNCTSCSYKNPC1 | |
| SCHEMBL3242121 | 0.88 | BRAF (0.53) | BRAFFYNCTSCSYKNPC1 | |
| SCHEMBL3242919 | 0.87 | BRAF (0.47) | BRAFFYNCTSCSYKEGFR | |
| SCHEMBL3244240 | 0.86 | BRAF (0.69) | BRAFTEKFYNCDK8CHRNA7 | |
| SCHEMBL3246808 | 0.84 | CTSC (0.64) | BRAFTEKCTSCSYKCDK8 | |
| SCHEMBL3244032 | 0.82 | KDR (0.48) | BRAFTEKFYNCTSCKDR | |
| SCHEMBL3246352 | 0.82 | CTSC (0.53) | CTSCSYKMAPTKMT2A | |
| SCHEMBL3247795 | 0.82 | BRAF (0.46) | BRAFFYNMTNR1AMTNR1BCTSC | |
| SCHEMBL3235430 | 0.82 | CTSC (0.46) | BRAFFYNCTSCSYKEGFR | |
| SCHEMBL3249551 | 0.81 | CTSC (0.45) | BRAFFYNCTSCSYKEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010057833-A1 | COMPOUNDS FOR TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY | BIOMARIN IGA, LTD. (BS) | 2010-05-27 | — | — | WO | claimed |
| WO-2010057833-A1 | COMPOUNDS FOR TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY | BIOMARIN IGA, LTD. (BS) | 2010-05-27 | — | — | WO | disclosed |