Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 2/20 | 0.69 |
| ▸ | ABL1 | P00519 | 5/20 | 0.56 |
| ▸ | FYN | P06241 | 2/20 | 0.51 |
| ▸ | GSK3B | P49841 | 1/20 | 0.51 |
| ▸ | TEK | Q02763 | 1/20 | 0.50 |
| ▸ | BCR | P11274 | 3/20 | 0.49 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.49 |
| ▸ | HTR2A | P28223 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | CDK8 | P49336 | 1/20 | 0.48 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.47 |
| ▸ | KIT | P10721 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3247802 | 0.92 | BRAF (0.58) | BRAFABL1FYNKDM4EMAPT | |
| SCHEMBL3242880 | 0.86 | BRAF (0.54) | BRAFABL1FYNTEKBCR | |
| SCHEMBL3242870 | 0.84 | BRAF (0.62) | BRAFFYNKDM4EMAPTMAPK1 | |
| SCHEMBL3246505 | 0.84 | BRAF (0.53) | BRAFFYNKDM4EMAPTMAPK1 | |
| SCHEMBL3238228 | 0.83 | NPC1 (0.59) | BRAFFYNKDM4EMAPTMAPK1 | |
| SCHEMBL4183190 | 0.83 | BRAF (0.71) | BRAFABL1FYNCHRNA7HTR2A | |
| SCHEMBL3249357 | 0.83 | NPC1 (0.59) | BRAFABL1FYNBCR | |
| SCHEMBL3246389 | 0.82 | CTSC (0.58) | BRAFFYNTEKKDM4EMAPT | |
| SCHEMBL1122219 | 0.82 | BRAF (1.00) | BRAFFYN | |
| SCHEMBL3244032 | 0.82 | KDR (0.48) | BRAFFYNTEKHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010057833-A1 | COMPOUNDS FOR TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY | BIOMARIN IGA, LTD. (BS) | 2010-05-27 | — | — | WO | claimed |
| WO-2010057833-A1 | COMPOUNDS FOR TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY | BIOMARIN IGA, LTD. (BS) | 2010-05-27 | — | — | WO | disclosed |