Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 6/20 | 0.58 |
| ▸ | FYN | P06241 | 3/20 | 0.55 |
| ▸ | SYK | P43405 | 2/20 | 0.49 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.48 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.48 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.48 |
| ▸ | CDK2 | P24941 | 1/20 | 0.48 |
| ▸ | CDK9 | P50750 | 1/20 | 0.48 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.48 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.48 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.48 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.48 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.48 |
| ▸ | CTSC | P53634 | 1/20 | 0.48 |
| ▸ | ABL1 | P00519 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3242880 | 0.93 | BRAF (0.54) | BRAFFYNSYKCTSCABL1 | |
| SCHEMBL3244240 | 0.92 | BRAF (0.69) | BRAFFYNABL1MAPTKDM4E | |
| SCHEMBL3244032 | 0.90 | KDR (0.48) | BRAFFYNCTSCKDR | |
| SCHEMBL3242121 | 0.89 | BRAF (0.53) | BRAFFYNSYKCTSCABL1 | |
| SCHEMBL3247795 | 0.89 | BRAF (0.46) | BRAFFYNCTSCKDRNPC1 | |
| SCHEMBL3244837 | 0.87 | FYN (0.57) | BRAFFYNSYKCTSCEGFR | |
| SCHEMBL3249357 | 0.87 | NPC1 (0.59) | BRAFFYNABL1MEN1NPC1 | |
| SCHEMBL3246505 | 0.86 | BRAF (0.53) | BRAFFYNSYKKDRMEN1 | |
| SCHEMBL3242919 | 0.86 | BRAF (0.47) | BRAFFYNSYKCTSCABL1 | |
| SCHEMBL3235430 | 0.85 | CTSC (0.46) | BRAFFYNSYKCTSCABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010057833-A1 | COMPOUNDS FOR TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY | BIOMARIN IGA, LTD. (BS) | 2010-05-27 | — | — | WO | claimed |
| WO-2010057833-A1 | COMPOUNDS FOR TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY | BIOMARIN IGA, LTD. (BS) | 2010-05-27 | — | — | WO | disclosed |