Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP3 | P42574 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.32 |
| ▸ | POLB | P06746 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | MMP2 | P08253 | 1/20 | 0.30 |
| ▸ | MMP9 | P14780 | 1/20 | 0.30 |
| ▸ | MMP14 | P50281 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 3/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.30 |
| ▸ | USP2 | O75604 | 2/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | ESR1 | P03372 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3254823 | 1.00 | CASP3 (0.33) | CASP3KDM4EPOLBMAPTLMNA | |
| Hydrochloric Acid SCHEMBL3249857 | 0.88 | CASP3 (0.33) | CASP3KDM4EPOLBHSD17B10MEN1 | |
| Hydrochloric Acid SCHEMBL3252442 | 0.88 | CASP3 (0.33) | CASP3KDM4EPOLBHSD17B10MEN1 | |
| SCHEMBL3255160 | 0.86 | MAPT (0.38) | KDM4EPOLBMAPTLMNATP53 | |
| SCHEMBL3252606 | 0.84 | ALDH1A1 (0.36) | KDM4EPOLBMAPTLMNATP53 | |
| SCHEMBL3254901 | 0.83 | KDM4E (0.38) | CASP3KDM4EPOLBMAPTLMNA | |
| SCHEMBL3245465 | 0.82 | ALDH1A1 (0.36) | KDM4EPOLBMAPTLMNATP53 | |
| SCHEMBL3243030 | 0.82 | MAPT (0.34) | KDM4EPOLBMAPTLMNATP53 | |
| SCHEMBL3251355 | 0.81 | ALDH1A1 (0.37) | KDM4EPOLBMAPTLMNATP53 | |
| SCHEMBL3251597 | 0.81 | PARG (0.47) | KDM4EPOLBMAPTLMNATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899335-B1 | PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | PF MEDICAMENT (FR) | 2010-05-19 | — | — | EP | claimed |