Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | MAPT | P10636 | 5/20 | 0.36 |
| ▸ | POLB | P06746 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | CRHBP | P24387 | 1/20 | 0.33 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3255160 | 0.95 | MAPT (0.38) | ALDH1A1MAPTPOLBHPGDLMNA | |
| SCHEMBL3252606 | 0.92 | ALDH1A1 (0.36) | ALDH1A1MAPTPOLBHPGDLMNA | |
| SCHEMBL3254901 | 0.92 | KDM4E (0.38) | ALDH1A1MAPTPOLBHPGDLMNA | |
| SCHEMBL3251355 | 0.91 | ALDH1A1 (0.37) | ALDH1A1MAPTPOLBHPGDLMNA | |
| Hydrochloric Acid SCHEMBL3249006 | 0.88 | SLC6A2 (0.43) | ALDH1A1MAPTPOLBHPGDLMNA | |
| SCHEMBL3241985 | 0.87 | MAPT (0.42) | ALDH1A1MAPTPOLBHPGDLMNA | |
| SCHEMBL3245494 | 0.85 | PARG (0.42) | ALDH1A1MAPTPOLBLMNATP53 | |
| SCHEMBL3243030 | 0.84 | MAPT (0.34) | ALDH1A1MAPTPOLBHPGDLMNA | |
| SCHEMBL3242992 | 0.84 | RXFP1 (0.35) | ALDH1A1MAPTPOLBHPGDLMNA | |
| SCHEMBL3241913 | 0.83 | KDM4E (0.51) | ALDH1A1MAPTPOLBHPGDLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899335-B1 | PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | PF MEDICAMENT (FR) | 2010-05-19 | — | — | EP | claimed |