Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.35 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.35 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.35 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.33 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.33 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.33 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | PRKAB2 | O43741 | 6/20 | 0.33 |
| ▸ | PRKAG1 | P54619 | 6/20 | 0.33 |
| ▸ | PRKAA2 | P54646 | 6/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3250055 | 0.83 | POLB (0.43) | BCL2L1MCL1NPY5RKMT2AMEN1 | |
| SCHEMBL4172113 | 0.81 | CSNK2A2 (0.40) | CSNK2A2CSNK2BCSNK2A1PRKAB2PRKAG1 | |
| SCHEMBL3244399 | 0.78 | GAA (0.41) | CSNK2A2CSNK2BCSNK2A1KMT2AMEN1 | |
| SCHEMBL3245352 | 0.78 | HTR2C (0.42) | BCL2L1MCL1KMT2AMEN1ALDH1A1 | |
| SCHEMBL3251618 | 0.77 | HTR4 (0.36) | ATMCNR2KMT2AMEN1TSHR | |
| SCHEMBL3251461 | 0.77 | KDM4E (0.33) | CNR2HSD17B10 | |
| SCHEMBL3254879 | 0.77 | PRKAG1 (0.40) | MCL1CSNK2A2CSNK2BCSNK2A1KMT2A | |
| SCHEMBL3253927 | 0.77 | CSNK2A2 (0.33) | CSNK2A2CSNK2BCSNK2A1KMT2AMEN1 | |
| SCHEMBL3253930 | 0.77 | CSNK2A2 (0.33) | CSNK2A2CSNK2BCSNK2A1KMT2AMEN1 | |
| Hydrochloric Acid SCHEMBL3250727 | 0.76 | CSNK2A2 (0.32) | CSNK2A2CSNK2BCSNK2A1PRKAB2PRKAG1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899335-B1 | PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | PF MEDICAMENT (FR) | 2010-05-19 | — | — | EP | disclosed |
| EP-1899335-A1 | PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | PIERRE FABRE MEDICAMENT (FR) | 2008-03-19 | — | — | EP | disclosed |
| WO-2007003611-A1 | PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | PIERRE FABRE MEDICAMENT (FR) | 2007-01-11 | — | — | WO | disclosed |