Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | PRKAG1 | P54619 | 12/20 | 0.37 |
| ▸ | PRKAA1 | Q13131 | 12/20 | 0.37 |
| ▸ | PRKAB1 | Q9Y478 | 12/20 | 0.37 |
| ▸ | PRKAB2 | O43741 | 11/20 | 0.37 |
| ▸ | PRKAA2 | P54646 | 11/20 | 0.37 |
| ▸ | PRKAG3 | Q9UGI9 | 11/20 | 0.37 |
| ▸ | PRKAG2 | Q9UGJ0 | 11/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CSNK2A2 | P19784 | 2/20 | 0.34 |
| ▸ | CSNK2B | P67870 | 2/20 | 0.34 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3245870 | 0.89 | PKM (0.39) | GAAPKMPRKAG1PRKAA1PRKAB1 | |
| SCHEMBL3254879 | 0.88 | PRKAG1 (0.40) | PRKAG1PRKAA1PRKAB1PRKAB2PRKAA2 | |
| SCHEMBL3247132 | 0.88 | PKM (0.39) | GAAPKMPRKAG1PRKAA1PRKAB1 | |
| SCHEMBL4171744 | 0.83 | PKM (0.35) | GAAPKM | |
| SCHEMBL3250056 | 0.82 | GAA (0.47) | GAAMEN1ALDH1A1KMT2A | |
| SCHEMBL4172113 | 0.81 | CSNK2A2 (0.40) | PRKAG1PRKAA1PRKAB1PRKAB2PRKAA2 | |
| SCHEMBL3244394 | 0.78 | BCL2L1 (0.39) | PRKAG1PRKAA1PRKAB1PRKAB2PRKAA2 | |
| SCHEMBL3247121 | 0.77 | GAA (0.44) | GAAMEN1ALDH1A1KMT2A | |
| SCHEMBL3253930 | 0.77 | CSNK2A2 (0.33) | GAAPRKAG1PRKAA1PRKAB1PRKAB2 | |
| SCHEMBL3253927 | 0.77 | CSNK2A2 (0.33) | GAAPRKAG1PRKAA1PRKAB1PRKAB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899335-B1 | PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | PF MEDICAMENT (FR) | 2010-05-19 | — | — | EP | disclosed |
| EP-1899335-A1 | PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | PIERRE FABRE MEDICAMENT (FR) | 2008-03-19 | — | — | EP | disclosed |
| WO-2007003611-A1 | PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | PIERRE FABRE MEDICAMENT (FR) | 2007-01-11 | — | — | WO | disclosed |