Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 7/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 7/20 | 0.34 |
| ▸ | HPGD | P15428 | 6/20 | 0.34 |
| ▸ | TP53 | P04637 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | PRKAB2 | O43741 | 2/20 | 0.33 |
| ▸ | PRKAG1 | P54619 | 2/20 | 0.33 |
| ▸ | PRKAA2 | P54646 | 2/20 | 0.33 |
| ▸ | PRKAA1 | Q13131 | 2/20 | 0.33 |
| ▸ | PRKAG3 | Q9UGI9 | 2/20 | 0.33 |
| ▸ | PRKAG2 | Q9UGJ0 | 2/20 | 0.33 |
| ▸ | PRKAB1 | Q9Y478 | 2/20 | 0.33 |
| ▸ | USP2 | O75604 | 4/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4157558 | 0.88 | HTR6 (0.31) | HTR6 | |
| SCHEMBL3266855 | 0.84 | PRKAB2 (0.33) | KDM4EMEN1KMT2AADRB2RECQL | |
| SCHEMBL3266861 | 0.84 | PRKAB2 (0.33) | KDM4EMEN1KMT2AADRB2RECQL | |
| SCHEMBL3266851 | 0.84 | PRKAB2 (0.33) | KDM4EMEN1KMT2AADRB2RECQL | |
| SCHEMBL3251058 | 0.83 | MAPT (0.37) | KDM4EMEN1KMT2AADRB2RECQL | |
| SCHEMBL3251059 | 0.83 | MAPT (0.37) | KDM4EMEN1KMT2AADRB2RECQL | |
| Hydrochloric Acid SCHEMBL3254760 | 0.83 | MAPT (0.36) | KDM4EMEN1KMT2AADRB2RECQL | |
| Hydrochloric Acid SCHEMBL3254764 | 0.83 | MAPT (0.36) | KDM4EMEN1KMT2AADRB2RECQL | |
| SCHEMBL3245506 | 0.82 | LMNA (0.37) | KDM4EMEN1KMT2AADRB2RECQL | |
| SCHEMBL3244775 | 0.82 | LMNA (0.37) | KDM4EMEN1KMT2AADRB2RECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899335-B1 | PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | PF MEDICAMENT (FR) | 2010-05-19 | — | — | EP | disclosed |
| EP-1899335-A1 | PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | PIERRE FABRE MEDICAMENT (FR) | 2008-03-19 | — | — | EP | disclosed |
| WO-2007003611-A1 | PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | PIERRE FABRE MEDICAMENT (FR) | 2007-01-11 | — | — | WO | disclosed |