Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM6B | O15054 | 6/20 | 0.38 |
| ▸ | KDM4C | Q9H3R0 | 6/20 | 0.38 |
| ▸ | GAA | P10253 | 3/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.33 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.33 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA7 | P43166 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | ALPL | P05186 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3245093 | 0.82 | CA1 (0.49) | KDM4COPRM1OPRK1CA1CA2 | |
| SCHEMBL3245087 | 0.82 | OPRM1 (0.45) | GAAOPRM1OPRK1OPRD1ALDH1A1 | |
| SCHEMBL3243959 | 0.79 | CA1 (0.48) | KDM4COPRM1OPRK1CA1CA2 | |
| SCHEMBL917364 | 0.79 | ALDH1A1 (0.52) | GAAOPRM1OPRK1OPRD1ALDH1A1 | |
| SCHEMBL3246830 | 0.76 | BCHE (0.54) | KDM4CKMT2A | |
| SCHEMBL918901 | 0.75 | ALDH1A1 (0.51) | GAAOPRM1OPRK1OPRD1ALDH1A1 | |
| SCHEMBL3253489 | 0.73 | BCHE (0.53) | KDM4CKMT2A | |
| SCHEMBL16057499 | 0.71 | GAA (0.47) | KDM6BKDM4CGAAALDH1A1KDM4E | |
| SCHEMBL7167293 | 0.70 | ALDH1A1 (0.48) | GAAOPRM1OPRK1ALDH1A1KDM4E | |
| SCHEMBL3254053 | 0.70 | OPRM1 (0.43) | OPRM1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1227803-B1 | COMPOUNDS FOR INHIBITING IAPP-ASSOCIATED AMYLOID DEPOSITS | BELLUS HEALTH INTERNATIONAL LTD (CH) | 2010-05-05 | — | — | EP | claimed |
| US-6562836-B1 | Islet amyloid polypeptide (IAPP) is known to be capable of forming fibrils which are deposited in the pancreas of patients wtih type II diabetes | QUEEN'S UNIVERSITY OF KINGSTON (CA) | 2003-05-13 | — | — | US | claimed |