Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 6/20 | 0.45 |
| ▸ | GABRB2 | P47870 | 5/20 | 0.45 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.45 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.45 |
| ▸ | DAO | P14920 | 3/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.42 |
| ▸ | PPARG | P37231 | 2/20 | 0.38 |
| ▸ | CSF1R | P07333 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | TYMS | P04818 | 1/20 | 0.36 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.36 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.36 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.36 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3254010 | 0.87 | GABRA1 (0.39) | GABRA1GABRB2GABRA3GABRB1PARP1 | |
| SCHEMBL3252380 | 0.86 | CSF1R (0.43) | GABRA1GABRB2GABRA3GABRB1CSF1R | |
| SCHEMBL3263920 | 0.85 | DAO (0.38) | GABRA1GABRB2GABRA3GABRB1DAO | |
| SCHEMBL3254675 | 0.84 | ALDH1A1 (0.42) | GABRA1GABRB2GABRA3GABRB1CSF1R | |
| SCHEMBL3255978 | 0.84 | FEN1 (0.39) | GABRA1GABRB2GABRA3GABRB1DAO | |
| SCHEMBL3251814 | 0.84 | GABRA1 (0.56) | GABRA1GABRB2GABRA3GABRB1DAO | |
| SCHEMBL3251108 | 0.84 | ALDH1A1 (0.43) | MEN1KMT2A | |
| SCHEMBL3249200 | 0.83 | TUBB4A (0.41) | GABRA1GABRB2GABRA3GABRB1CSF1R | |
| SCHEMBL3245670 | 0.83 | CSF1R (0.37) | GABRA1GABRB2GABRA3GABRB1CSF1R | |
| SCHEMBL3255154 | 0.83 | IP6K1 (0.39) | GABRA1GABRB2GABRA3GABRB1CSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899335-B1 | PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | PF MEDICAMENT (FR) | 2010-05-19 | — | — | EP | claimed |