Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 5/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
| ▸ | CASP7 | P55210 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | PNMT | P11086 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 3/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20743845 | 0.84 | PKM (0.54) | MAPTGAAHTTMAPK1ALDH1A1 | |
| SCHEMBL30309604 | 0.84 | PKM (0.54) | MAPTGAAHTTMAPK1ALDH1A1 | |
| SCHEMBL14433417 | 0.82 | HTT (0.58) | MAPTGAAALOX12HTTLMNA | |
| SCHEMBL2472213 | 0.81 | ALDH1A1 (0.59) | MAPTGAALMNAMAPK1ALDH1A1 | |
| SCHEMBL22558321 | 0.78 | CYP19A1 (0.59) | MAPTGAAALOX12HTTLMNA | |
| SCHEMBL2472829 | 0.78 | APEX1 (0.54) | GAAALDH1A1KMT2AKDM4ETDP1 | |
| SCHEMBL19771455 | 0.77 | LMNA (0.54) | GAAHTTLMNAMAPK1SMN1; SMN2 | |
| SCHEMBL17430764 | 0.77 | MAPK1 (0.63) | MAPTGAAALOX12HTTLMNA | |
| SCHEMBL1793139 | 0.77 | MEN1 (0.49) | MAPTLMNAMAPK1SMN1; SMN2ALDH1A1 | |
| SCHEMBL1015753 | 0.76 | GAA (0.40) | GAAHTTLMNAALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010002998-A1 | 2,4,6-TRISUBSTITUTED PYRIDO (3,2-d) PYRIMIDINES USEFUL FOR TREATING VIRAL INFECTIONS | GILEAD SCIENCES, INC. (US) | 2010-01-07 | — | — | WO | disclosed |